Girkin Christopher A, Sample Pamela A, Liebmann Jeffrey M, Jain Sonia, Bowd Christopher, Becerra Lida M, Medeiros Felipe A, Racette Lyne, Dirkes Keri A, Weinreb Robert N, Zangwill Linda M
Callahan Eye Foundation Hospital, University of Alabama at Birmingham Glaucoma Service, 700 S 18th St, Fourth Floor, Ste 406, Birmingham, AL, USA.
Arch Ophthalmol. 2010 May;128(5):541-50. doi: 10.1001/archophthalmol.2010.49.
To define differences in optic disc, retinal nerve fiber layer, and macular structure between healthy participants of African (AD) and European descent (ED) using quantitative imaging techniques in the African Descent and Glaucoma Evaluation Study (ADAGES).
Reliable images were obtained using stereoscopic photography, confocal scanning laser ophthalmoscopy (Heidelberg retina tomography [HRT]), and optical coherence tomography (OCT) for 648 healthy subjects in ADAGES. Findings were compared and adjusted for age, optic disc area, and reference plane height where appropriate.
The AD participants had significantly greater optic disc area on HRT (2.06 mm(2); P < .001) and OCT (2.47 mm(2); P < .001) and a deeper HRT cup depth than the ED group (P < .001). Retinal nerve fiber layer thickness was greater in the AD group except within the temporal region, where it was significantly thinner. Central macular thickness and volume were less in the AD group.
Most of the variations in optic nerve morphologic characteristics between the AD and ED groups are due to differences in disc area. However, differences remain in HRT cup depth, OCT macular thickness and volume, and OCT retinal nerve fiber layer thickness independent of these variables. These differences should be considered in the determination of disease status.
在非裔血统与青光眼评估研究（ADAGES）中，使用定量成像技术确定非洲裔（AD）和欧洲裔（ED）健康参与者在视盘、视网膜神经纤维层和黄斑结构上的差异。
在ADAGES研究中，使用立体摄影、共焦扫描激光眼底镜检查（海德堡视网膜断层扫描[HRT]）和光学相干断层扫描（OCT）为648名健康受试者获取可靠图像。对结果进行比较，并在适当情况下根据年龄、视盘面积和参考平面高度进行调整。
AD参与者在HRT上的视盘面积显著更大（2.06平方毫米；P <.001），在OCT上也更大（2.47平方毫米；P <.001），并且HRT杯深度比ED组更深（P <.001）。除了颞侧区域视网膜神经纤维层厚度显著更薄外，AD组的视网膜神经纤维层厚度更大。AD组的中央黄斑厚度和体积更小。
AD组和ED组之间视神经形态特征的大多数差异是由于视盘面积的不同。然而，独立于这些变量，HRT杯深度、OCT黄斑厚度和体积以及OCT视网膜神经纤维层厚度仍存在差异。在确定疾病状态时应考虑这些差异。
