Yang Guang-Yu, Wang Rui-Rui, Gao Zhong-Hua, Lia Yin-Ke, Yang Liu-Meng, Li Xiao-Nian, Shang Shan-Zhai, Zheng Yong-Tang, Xiao Wei-Lie, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, PR China.
Nat Prod Commun. 2013 Apr;8(4):467-70.
Three new dibenzocyclooctadiene lignans, marlignans M-O (1-3), together two known ones, were isolated from the leaves and stems of Schisandra wilsoniana. The structures of 1-3 were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 2 showed anti-HIV-1 activity with an EC50 value of 5.82 microg/mL and a therapeutic index (TI) of more than 12.8. Compound 3 showed obvious bioactivity in inhibiting Epstein-Barr virus early antigen (EBV-EA) activation.
从华中五味子的叶和茎中分离出三种新的二苯并环辛二烯木脂素，即木兰脂素M - O（1 - 3），以及另外两种已知的木脂素。通过光谱方法，包括广泛的一维和二维核磁共振技术，阐明了1 - 3的结构。化合物2表现出抗HIV - 1活性，EC50值为5.82微克/毫升，治疗指数（TI）大于12.8。化合物3在抑制爱泼斯坦 - 巴尔病毒早期抗原（EBV - EA）激活方面表现出明显的生物活性。
