两例因过量服用反苯环丙胺导致的致命中毒病例。

Two cases of fatal intoxication due to tranylcypromine overdose.

作者信息

Boniface P J

机构信息

Chemistry Division, Department of Scientific and Industrial Research, Auckland, New Zealand.

出版信息

J Anal Toxicol. 1991 Jan-Feb;15(1):38-40. doi: 10.1093/jat/15.1.38.

DOI:10.1093/jat/15.1.38

PMID:2046340

Abstract

Two cases of death following the ingestion of tranylcypromine are presented. High concentrations of tranylcypromine were determined in blood, urine, and liver by gas-liquid chromatography. Tranylcypromine was extracted from buffered blood with n-butyl chloride. The evaporated extract was derivatized with trifluoroacetic anhydride and analyzed by gas chromatography with nitrogen-phosphorus selective detection. The method was linear in blood over the range 0.5-20 mg/L with a limit of quantitation of about 0.2 mg/L.

摘要

本文报告了两例因摄入反苯环丙胺而死亡的病例。通过气液色谱法测定了血液、尿液和肝脏中反苯环丙胺的高浓度。用正丁基氯从缓冲血液中提取反苯环丙胺。将蒸发后的提取物用三氟乙酸酐衍生化，并用氮磷选择性检测气相色谱法进行分析。该方法在血液中0.5 - 20 mg/L范围内呈线性，定量限约为0.2 mg/L。