Matioli Maria Niures P S, Caramelli Paulo
Department of Geriatrics, Lusíada University School of Medicine, Santos, SP, Brazil.
Arq Neuropsiquiatr. 2010 Apr;68(2):185-8. doi: 10.1590/s0004-282x2010000200006.
To investigate the diagnostic value of brief cognitive tests in differentiating vascular dementia (VaD) from Alzheimer's disease (AD).
Fifteen patients with mild VaD, 15 patients with mild probable AD and 30 healthy controls, matched for age, education and dementia severity, were submitted to the following cognitive tests: clock drawing (free drawing and copy), category and letter fluency, delayed recall test of figures and the EXIT 25 battery.
VaD patients performed worse than AD patients in category fluency (p=0.014), letter fluency (p=0.043) and CLOX 2 (p=0.023), while AD cases performed worse than VaD patients in delayed recall (p=0.013). However, ROC curves for these tests displayed low sensitivity and specificity for the differential diagnosis between VaD and AD.
Although the performance of VaD and AD patients was significantly different in some cognitive tests, the value of such instruments in differentiating VaD from AD proved to be very limited.
探讨简易认知测试在鉴别血管性痴呆（VaD）与阿尔茨海默病（AD）中的诊断价值。
选取15例轻度VaD患者、15例轻度可能的AD患者以及30名年龄、教育程度和痴呆严重程度相匹配的健康对照者，进行以下认知测试：画钟试验（自由绘图和临摹）、类别流畅性和字母流畅性、图形延迟回忆测试以及EXIT 25成套测验。
VaD患者在类别流畅性（p = 0.014）、字母流畅性（p = 0.043）和CLOX 2（p = 0.023）方面的表现比AD患者差，而AD患者在延迟回忆方面比VaD患者差（p = 0.013）。然而，这些测试的ROC曲线显示，其对VaD和AD的鉴别诊断敏感性和特异性较低。
尽管VaD和AD患者在某些认知测试中的表现存在显著差异，但这些测试工具在鉴别VaD和AD方面的价值非常有限。
