Nersessian A K, Zilfian V N, Koumkoumadjian V A
V.A. Fanardjian Centre for Oncology Research, Yerevan, Armenia, U.S.S.R.
Mutat Res. 1991 Jun;260(2):215-8. doi: 10.1016/0165-1218(91)90010-j.
We studied the in vivo effect of rat immunization with tularemia live vaccine (TLV) on chromosomal aberrations (CA) induced in bone marrow cells by 4 anthracycline antibiotics. CA induced by adriamycin (ADR) and 4'-epiadriamycin (EADR) in rat bone marrow cells consisted mainly of chromatid breaks (approximately 90%), whereas lesions induced by aclacur (AC) and aclarubicin (ACR) consisted only of chromatid breaks. Preliminary cutaneous immunization of rats with TLV revealed significant suppression of CA induced by all 4 antibiotics. The present and previous results suggest that TLV may be a potent anticlastogenic factor.
我们研究了用土拉菌活疫苗（TLV）对大鼠进行免疫接种后，其对4种蒽环类抗生素诱导的骨髓细胞染色体畸变（CA）的体内影响。阿霉素（ADR）和4'-表阿霉素（EADR）诱导的大鼠骨髓细胞CA主要由染色单体断裂组成（约90%），而阿克拉霉素（AC）和阿柔比星（ACR）诱导的损伤仅由染色单体断裂组成。用TLV对大鼠进行初步皮肤免疫显示，所有4种抗生素诱导的CA均受到显著抑制。目前和先前的结果表明，TLV可能是一种有效的抗致断裂因子。
