Nersesian A K
Eksp Onkol. 1985;7(1):38-40.
The living tularemia vaccine is studied for its effect on rat tumours and chromosome aberrations in bone marrow cells during 3,4-benz(a)pyrene injection (BP). It is established that a single epicutaneous vaccination of rats decreases the incidence of BP-induced tumours, prolongs the latent period and reduces the mean weight of tumours as well as lowers the number of myelocaryocytes with chromosome aberrations when BP is administered 15 days after immunization. 125 days after a single subcutaneous injection of BP in a dose of 4 mg the tumours appeared in 57% of animals and in 35% of preliminarily immunized animals. 24 h after intraperitoneal administration of 4 mg of BP the immunized rats revealed a 35% decrease in the amount of chromosome aberrations in myelocaryocytes as compared to the nonimmunized rats.
研究了活的兔热病疫苗对大鼠肿瘤的影响以及在注射3,4-苯并(a)芘（BP）期间对骨髓细胞染色体畸变的影响。结果表明，对大鼠进行单次表皮接种可降低BP诱导肿瘤的发生率，延长潜伏期，减轻肿瘤平均重量，并且在免疫后15天给予BP时，可减少具有染色体畸变的骨髓细胞数量。在以4mg剂量单次皮下注射BP后125天，57%的动物出现肿瘤，而预先免疫的动物中这一比例为35%。在腹腔注射4mg BP后24小时，与未免疫的大鼠相比，免疫大鼠骨髓细胞中染色体畸变数量减少了35%。
