Nersesian A K, Zil'fian V N, Kumkumadzhian V A, Fichidzhian B S
Tsitologiia. 1986 Apr;28(4):457-60.
Cytogenetic disturbances due to cytostatic preparations--cyclophosphamide and methylnitrosourea--applied as single or ten-times administrations in different doses have been studied for rats immunized with tularemia live dried vaccine. It is established that with the application of these preparations to immunized animals the quantity of chromosomal aberrations in myelokaryocytes decreased from 1.4 to 2.2 times, compared with that in non-immunized animals.
研究了用土拉菌冻干活疫苗免疫的大鼠，单次或十次给予不同剂量的细胞抑制剂——环磷酰胺和甲基亚硝基脲——所导致的细胞遗传学紊乱。结果表明，将这些制剂应用于免疫动物时，与未免疫动物相比，骨髓细胞中的染色体畸变数量减少了1.4至2.2倍。
