Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Suita, Osaka, Japan.
J Atheroscler Thromb. 2010 Aug 31;17(8):828-33. doi: 10.5551/jat.3798. Epub 2010 May 13.
The effects of exercise intervention and to assess its long-term efficacy in preventing subsequent cardiovascular events in patients with type 2 diabetes were little known on randomized controlled trial.
Thirty-eight type 2 diabetic patients (21 men and 17 women) were assigned to either the exercise group (n=21) or the control group without exercise training (n=17) by simple randomization. The exercise training group was scheduled for aerobic and resistance exercise programs for 3 months. After the 3-month, we investigated endothelial function, insulin resistance, adipocytokines and inflammatory markers. The endothelial function was evaluated by examining a flow-mediated endothelium-dependent vasodilatation (FMD). Furthermore, we followed the incidence of cardiovascular events for 24 months.
After 3-month, HbA1C was decreased significantly in both groups. FMD was increased from 7.3+/-4.7% to 10.9+/-6.2% only in the exercise group (p<0.05). Long-term follow-up data showed that the control group developed cardiovascular events more frequently than did the exercise group (p<0.05).
Exercise improves endothelial dysfunction independently of glycemic control and insulin sensitivity in patients with type 2 diabetes. The beneficial effects of 3-month exercise to reduce cardiovascular events persist for 24 months.
运动干预的效果及其在预防 2 型糖尿病患者随后发生心血管事件方面的长期疗效，在随机对照试验中知之甚少。
38 例 2 型糖尿病患者（男 21 例，女 17 例）采用简单随机分组法分为运动组（n=21）和无运动训练对照组（n=17）。运动组进行 3 个月的有氧运动和抗阻运动训练。3 个月后，我们检测内皮功能、胰岛素抵抗、脂肪细胞因子和炎症标志物。内皮功能通过血流介导的内皮依赖性血管舒张（FMD）来评估。此外，我们随访了 24 个月的心血管事件发生率。
3 个月后，两组的糖化血红蛋白（HbA1C）均显著降低。仅运动组的 FMD 从 7.3+/-4.7%增加到 10.9+/-6.2%（p<0.05）。长期随访数据显示，对照组发生心血管事件的频率高于运动组（p<0.05）。
运动可改善 2 型糖尿病患者的内皮功能障碍，独立于血糖控制和胰岛素敏感性。3 个月运动降低心血管事件的有益作用可持续 24 个月。
