Xia Xin, Wang Zhaoxin, Yin Zhiwei, Yang Yanxia, Xu Yiting, Chen Zhuo
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, People's Republic of China.
Key Laboratory of Theoretical Organic Chemistry and Function Molecule, Ministry of Education, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, People's Republic of China.
Chem Biomed Imaging. 2023 Mar 13;1(8):683-691. doi: 10.1021/cbmi.3c00013. eCollection 2023 Nov 27.
Combining therapeutic and diagnostic capabilities in one dose using nanoparticles promises to push the biomedical field toward the next generation of personalized medicine. Magnetic graphitic nanocapsules (MGNs) represent a cutting-edge tool in the biomedical field because of their incomparable magnetic properties and versatile functionalization. This paper reviews a series of MGNs and provides instructive guidelines for the design of MGNs with enhanced properties. Then, we highlight recent progress in MGNs for biomedical application studies such as multimode imaging, magnetic navigation, imaging-guided therapy, and synergistic therapy. Finally, we discuss some future directions of MGNs that can produce pronounced effects in the biomedical field.
利用纳米颗粒在一剂中结合治疗和诊断能力有望推动生物医学领域迈向新一代个性化医学。磁性石墨纳米胶囊（MGNs）因其无与伦比的磁性和多功能官能化而成为生物医学领域的一种前沿工具。本文综述了一系列MGNs，并为设计具有增强性能的MGNs提供了指导性指南。然后，我们重点介绍了MGNs在生物医学应用研究中的最新进展，如多模态成像、磁导航、成像引导治疗和协同治疗。最后，我们讨论了MGNs在生物医学领域可能产生显著效果的一些未来发展方向。
