Department of Experimental and Clinical Medicine, University 'Magna Graecia', Viale Europa, 88100, Catanzaro, Italy.
Expert Rev Clin Immunol. 2009 Nov;5(6):789-800. doi: 10.1586/eci.09.46.
Celiac disease (CD) is an autoimmune gluten-dependent enteropathy characterized by atrophy of the intestinal villi that improves after a gluten-free diet. CD is often associated with extraintestinal manifestations. In the past few years, growing evidence has documented the involvement of skin diseases among the extraintestinal manifestations of CD. This association could be related to the impairment of intestinal absorption and motility, other than to immunological and hormonal changes. The aim of this review is to report all CD-associated skin manifestations described in the literature and to analyze the possible mechanisms involved in this association. The opportunity to evaluate the possible presence of CD in patients affected by skin disorders is discussed.
乳糜泻（CD）是一种自身免疫性、麸质依赖性肠病，其特征为绒毛萎缩，在无麸质饮食后可改善。CD 常伴有肠外表现。在过去几年中，越来越多的证据表明，皮肤疾病是 CD 的肠外表现之一。这种关联可能与肠道吸收和运动功能障碍有关，而不仅仅是与免疫和激素变化有关。本综述的目的是报告文献中描述的所有与 CD 相关的皮肤表现，并分析这种关联中涉及的可能机制。讨论了在患有皮肤疾病的患者中评估可能存在 CD 的机会。
