Dobson Brooke J, Mackintosh Colin G, Griffin J Frank T
Disease Research Laboratory, University of Otago, 720 Cumberland St., Dunedin, New Zealand.
Vet Immunol Immunopathol. 2010 Sep 15;137(1-2):93-8. doi: 10.1016/j.vetimm.2010.04.014. Epub 2010 Apr 28.
In young ruminants, as in most animals, the thymus and Peyer's patches (PP) play a key role in immune function. In sheep and cattle it has been shown that they follow a recognisable pattern of development throughout early life but a study of these tissues in red deer (Cervus elaphus) had not been previously conducted. Red deer are undergoing increasing domestication thus it was important to determine whether there were any significant differences between species. Samples from the thymus, jejunal PP and ileal PP were obtained from deer at 1, 1.5, 2, 3, 6, 9 and 12 months of age. Tissues were measured, processed and comparisons between the equivalent tissues in cattle and sheep were made. The thymus and Peyer's patches of red deer were observed to follow similar patterns of development and involution as in other ruminant species. The thymus was also observed to show a seasonal decrease in weight and cellular composition possibly due to nutritional and environmental stresses. Moreover, evidence for the prevailing idea that the ileal PP acts as primary lymphoid tissue in ruminants was obtained.
与大多数动物一样，在幼年反刍动物中，胸腺和派伊尔氏结（PP）在免疫功能中发挥着关键作用。在绵羊和牛中，已表明它们在整个幼年时期遵循可识别的发育模式，但此前尚未对马鹿（Cervus elaphus）的这些组织进行过研究。马鹿的驯化程度在不断提高，因此确定不同物种之间是否存在任何显著差异很重要。从1、1.5、2、3、6、9和12月龄的鹿身上获取胸腺、空肠派伊尔氏结和回肠派伊尔氏结的样本。对组织进行测量、处理，并与牛和羊的相应组织进行比较。观察到马鹿的胸腺和派伊尔氏结与其他反刍动物物种遵循相似的发育和退化模式。还观察到胸腺的重量和细胞组成呈现季节性下降，这可能是由于营养和环境压力所致。此外，还获得了支持回肠派伊尔氏结在反刍动物中作为主要淋巴组织这一普遍观点的证据。
