Ignatova Milena, Manolova Nevena, Rashkov Iliya, Markova Nadya, Kukeva Rositsa, Stoyanova Radostina, Georgieva Ani, Toshkova Reneta
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev St. Bl. 103A, BG-1113 Sofia, Bulgaria.
Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Bl. 26, BG-1113 Sofia, Bulgaria.
Polymers (Basel). 2021 Aug 12;13(16):2690. doi: 10.3390/polym13162690.
Novel poly(vinyl alcohol) (PVA)/chitosan (Ch)-based fibrous materials containing an ionizable model drug, 8-hydroxyquinoline-5-sulfonic acid (SQ), were successfully fabricated by electrospinning. Complexes between the components of the crosslinked PVA/Ch/SQ mats and Cu and Fe ions were formed. The coordination of these ions in the mats was examined by electron paramagnetic resonance spectroscopy (EPR). The microbiological screening against and revealed that both the incorporation of SQ in the mats and the complexation with Cu and Fe imparted to these materials antibacterial and antifungal activities. Moreover, the SQ-containing mats and their complexes displayed good cytotoxicity against human cervical HeLa tumor cells. The most prominent was the cytotoxicity of the Cu complex of the mats. The combined antibacterial, antifungal and in vitro antitumor activities render these novel materials promising candidates for wound dressing applications and for application in the local treatment of cervical tumors.
通过静电纺丝成功制备了含有可电离模型药物8-羟基喹啉-5-磺酸（SQ）的新型聚（乙烯醇）（PVA）/壳聚糖（Ch）基纤维材料。交联的PVA/Ch/SQ垫的组分与铜离子和铁离子之间形成了络合物。通过电子顺磁共振光谱（EPR）研究了这些离子在垫中的配位情况。针对[此处原文缺失两种微生物名称]的微生物筛选表明，垫中SQ的掺入以及与铜和铁的络合赋予了这些材料抗菌和抗真菌活性。此外，含SQ的垫及其络合物对人宫颈HeLa肿瘤细胞显示出良好的细胞毒性。最显著的是垫的铜络合物的细胞毒性。抗菌、抗真菌和体外抗肿瘤活性的结合使这些新型材料成为伤口敷料应用和宫颈肿瘤局部治疗应用的有前途的候选材料。
