用MedLite C6调Q开关Nd:YAG激光和α-熊果苷治疗难治性黄褐斑：一项前瞻性研究。
Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: a prospective study.
作者信息
Polnikorn Niwat
机构信息
Kasemrad Aesthetic Center, Kasemrad Prachacheun Hospital, Bangsue, Bangkok, Thailand.
出版信息
J Cosmet Laser Ther. 2010 Jun;12(3):126-31. doi: 10.3109/14764172.2010.487910.
OBJECTIVE
To evaluate the effectiveness of a Q-switched Nd:YAG laser (MedLite C6; HOYA ConBio, Fremont, CA, USA) and 7% alpha arbutin solution (Skin Advance Laboratory, Japan) in the treatment of melasma.
METHODS
This was a prospective study of 35 refractory melasma cases treated with 10 weekly laser sessions, two monthly follow-up treatments and topical 7% alpha arbutin solution. Clinical photographs and severity grading on a 5-point scale were carried out by an independent observer at each visit.
RESULTS
At 6 months, 30% of study subjects received results in the excellent clearance category (> 81% reduction of melasma) and 36.7% received good (51-80% reduction) clearance. Mild and transient side effects included discomfort during treatment, erythema, whitening of fine hair and urticaria. Three cases of mottling hypo-pigmentation (8.57%) and two cases of recurrence of melasma (5.71%) were recorded.
CONCLUSION
Combination therapy with the MedLite C6 and 7% alpha arbutin solution is an effective and well-tolerated treatment for refractory melasma.
目的
评估调Q开关Nd:YAG激光（MedLite C6；美国加利福尼亚州弗里蒙特市豪雅康生物公司）和7%α熊果苷溶液（日本皮肤先进实验室）治疗黄褐斑的有效性。
方法
这是一项前瞻性研究，对35例难治性黄褐斑患者进行治疗，每周进行10次激光治疗，每月进行2次后续治疗，并外用7%α熊果苷溶液。每次就诊时由一名独立观察者拍摄临床照片并采用5分制进行严重程度分级。
结果
6个月时，30%的研究对象获得了极佳的清除效果（黄褐斑减少>81%），36.7%获得了良好的清除效果（减少51 - 80%）。轻微且短暂的副作用包括治疗期间的不适、红斑、细毛发变白和荨麻疹。记录到3例斑点状色素减退（8.57%）和2例黄褐斑复发（5.71%）。
结论
MedLite C6与7%α熊果苷溶液联合治疗是一种治疗难治性黄褐斑的有效且耐受性良好的方法。
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