Département de Biologie Cellulaire et Infection, Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, France.
Bioessays. 2010 Jun;32(6):496-504. doi: 10.1002/bies.200900172.
Clathrin and the endocytosis machinery has recently been described as being required in mammalian cells for the internalization of large particles including pathogenic bacteria, fungi, and large viruses. These apparently unexpected observations, within the framework of the classical mechanisms for the formation of clathrin-coated vesicles, are now considered as examples of a new non-classical function of clathrin, which can promote the internalization of membrane domains associated to planar clathrin lattices. The role of actin downstream of clathrin seems to be critical for this still poorly characterized process. The historical frontier between endocytosis and phagocytosis is vanishing in the light of this new role for clathrin.
网格蛋白和胞吞作用机制最近被描述为在哺乳动物细胞中需要用于内化包括致病性细菌、真菌和大型病毒在内的大颗粒。这些在经典网格蛋白包被小泡形成机制框架内的明显意外观察结果，现在被认为是网格蛋白新的非经典功能的例子，它可以促进与平面网格蛋白晶格相关的膜结构域的内化。网格蛋白下游的肌动蛋白的作用对于这个仍然特征描述不足的过程似乎是关键的。鉴于网格蛋白的这一新作用，胞吞作用和吞噬作用之间的历史界限正在消失。
