Pizarro-Cerdá Javier, Charbit Alain, Enninga Jost, Lafont Frank, Cossart Pascale
Institut Pasteur, Unit 'Interactions Bactéries Cellules', Paris F-75015, France; INSERM, U604, Paris F-75015, France; INRA, USC2020, Paris F-75015, France.
Institut Necker-Enfants Malades, Team 'Pathogénie des Infections Systémiques', Paris F-75015, France; Université Paris Descarte, Sorbonne Paris Cité, Paris F-75015, France; CNRS, UMR8235, Paris F-75015, France; INSERM, U1151, Paris F-75015, France.
Semin Cell Dev Biol. 2016 Dec;60:155-167. doi: 10.1016/j.semcdb.2016.07.019. Epub 2016 Jul 19.
Bacterial pathogens display an impressive arsenal of molecular mechanisms that allow survival in diverse host niches. Subversion of plasma membrane and cytoskeletal functions are common themes associated to infection by both extracellular and intracellular pathogens. Moreover, intracellular pathogens modify the structure/stability of their membrane-bound compartments and escape degradation from phagocytic or autophagic pathways. Here, we review the manipulation of host membranes by Listeria monocytogenes, Francisella tularensis, Shigella flexneri and Yersinia spp. These four bacterial model pathogens exemplify generalized strategies as well as specific features observed during bacterial infection processes.
细菌病原体展现出一系列令人印象深刻的分子机制，使其能够在各种宿主生态位中存活。破坏质膜和细胞骨架功能是细胞外和细胞内病原体感染所共有的常见现象。此外，细胞内病原体还会改变其膜结合区室的结构/稳定性，并逃避吞噬或自噬途径的降解。在此，我们综述了单核细胞增生李斯特菌、土拉弗朗西斯菌、福氏志贺菌和耶尔森菌属对宿主膜的操控。这四种细菌模型病原体体现了细菌感染过程中观察到的一般策略以及特定特征。
