通过 1,3-偶极环加成反应合成新型吡唑衍生物及其抗真菌活性。
Synthesis and antifungal activities of new pyrazole derivatives via 1,3-dipolar cycloaddition reaction.
机构信息
Nankai University, Tianjin, China.
出版信息
Chem Biol Drug Des. 2010 May;75(5):489-93. doi: 10.1111/j.1747-0285.2010.00948.x.
Abstract
A series of cycloadducts--pyrazoles via 1,3-dipolar cycloaddition reactions of generated nitrilimines with N-(4-chloro-2-fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by (1)H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title compounds exhibit significant fungicidal activities against Corynespora cassiicola.
摘要
描述了一系列通过生成的亚硝胺与 N-(4-氯-2-氟苯基)马来酰亚胺的 1,3-偶极环加成反应生成的吡唑类环加成物。所合成的新型化合物通过 (1)H NMR、MS 和元素分析进行了表征。杀菌试验表明，大多数标题化合物对辣椒炭疽病菌具有显著的杀菌活性。
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