Department of Physics, University of Minho, Braga, Portugal.
Am J Ophthalmol. 2010 Jul;150(1):97-109.e1. doi: 10.1016/j.ajo.2010.02.003. Epub 2010 May 20.
To evaluate the effect of changing the pupil size on the corneal first-surface higher-order aberrations induced by different refractive treatments: standard laser in situ keratomileusis (LASIK), custom LASIK, and corneal refractive therapy.
Observational study.
Eighty-one right eyes from patients with a mean age of 29.94 +/- 7.5 years, of which 50 were female (61.7%), were analyzed retrospectively at the Clínica Oftalmológica NovoVision, Madrid, Spain. Corneal videokeratographic data were used to obtain corneal first-surface higher-order aberrations for aperture diameters from 3 to 8 mm using the Vol-CT software (Sarver & Associates, Inc). Total root mean square (RMS) and RMS for third- to sixth-order Zernike polynomials as well as spherical-like, coma-like, secondary astigmatism, and spherical plus coma-like variables were calculated.
We verified an increase in the higher-order aberration total RMS after treatments of 0.014 +/- 0.025 microm, 0.019 +/- 0.027 microm, and 0.018 +/- 0.031 microm for standard LASIK, custom LASIK, and corneal refractive therapy, respectively, for 3-mm pupil diameter. For the 8-mm aperture diameter, changes in total RMS increased by a factor of 50 compared with the variation for the 3-mm diameter up to 0.744 +/- 0.731 microm, 0.493 +/- 0.794 microm, and 0.973 +/- 1.055 microm for standard LASIK, custom LASIK, and corneal refractive therapy, respectively.
The 3 techniques increase the wavefront aberrations of the cornea and change the relative contribution of coma-like and spherical-like aberrations. For a large aperture (> 5 mm), corneal refractive therapy induces more spherical-like aberrations than standard and custom LASIK. However, no clinically or statistically significant differences existed for narrower apertures. Standard and custom LASIK did not display statistically significant differences regarding higher-order aberrations.
评估瞳孔大小变化对不同屈光治疗（标准 LASIK、定制 LASIK 和角膜屈光治疗）诱导的角膜前表面高阶像差的影响。
观察性研究。
回顾性分析西班牙马德里 Clínica Oftalmológica NovoVision 的 81 只右眼，患者平均年龄 29.94±7.5 岁，其中 50 只（61.7%）为女性。使用 Vol-CT 软件（Sarver & Associates，Inc.），根据角膜视频角膜地形图数据，获得 3 至 8mm 孔径的角膜前表面高阶像差。计算总均方根（RMS）和三阶至六阶 Zernike 多项式的 RMS 以及球差样、彗差样、二次散光和球差加彗差样变量。
我们发现，在 3mm 瞳孔直径下，标准 LASIK、定制 LASIK 和角膜屈光治疗后，高阶像差总 RMS 分别增加了 0.014±0.025μm、0.019±0.027μm 和 0.018±0.031μm。对于 8mm 孔径直径，总 RMS 的变化增加了 50 倍，与 3mm 直径的变化相比，分别增加到 0.744±0.731μm、0.493±0.794μm 和 0.973±1.055μm，标准 LASIK、定制 LASIK 和角膜屈光治疗。
这 3 种技术都会增加角膜的波前像差，并改变彗差样和球差样像差的相对贡献。对于较大的孔径（>5mm），角膜屈光治疗比标准和定制 LASIK 引起更多的球差样像差。然而，在较窄的孔径下，没有临床或统计学上的显著差异。标准和定制 LASIK 在高阶像差方面没有显示出统计学上的显著差异。
