Department of Ophthalmology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
J Refract Surg. 2010 May;26(5):348-55. doi: 10.3928/1081597X-20100218-03. Epub 2010 May 19.
To compare ocular higher order aberrations induced by corneal refractive therapy (CRT, Paragon Vision) to those produced by LASIK for patients with comparable levels of myopia.
A retrospective chart review of 11 patients who used CRT lenses and 12 patients who underwent LASIK for correction of low to moderate myopia was performed. Uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BSCVA), manifest refraction, and optical higher order aberrations were recorded before and 1 month after treatment for each patient.
The CRT group consisted of 11 patients (4 men, 7 women) with a mean age of 29.1+/-5.2 years (range: 23 to 40 years), and the LASIK group consisted of 12 patients (3 men, 9 women) with a mean age of 39.2+/-12.0 years (range: 23 to 60 years). Manifest refraction decreased statistically significantly from -2.81+/-1.05 diopters (D) at baseline to -0.77+/-0.64 D following CRT treatment at 1 month (P<.0001) and from -3.11+/-1.21 D at baseline to -0.43+/-0.27 D at 1 month after LASIK (P<.0001). Both CRT and LASIK exhibited no significant changes in total higher order aberrations for 4-mm pupils but induced statistically significant increases in total higher order aberrations for 6-mm pupils. Corneal refractive therapy and LASIK both exhibited statistically similar factors of change for total higher order aberrations and coma-like higher order aberrations for 6-mm pupils. Corneal refractive therapy demonstrated a statistically significant greater factor of increase in spherical-like higher order aberrations for 6-mm pupils (P=.01).
Contact lens corneal refractive therapy and LASIK can effectively correct myopia, but both increase higher order aberrations for 6-mm pupils to a similar degree. However, spherical-like aberrations were statistically significantly greater after CRT than after LASIK.
比较角膜屈光治疗（CRT，Paragon Vision）和 LASIK 治疗中低度近视患者的眼球高阶像差。
回顾性分析了 11 例使用 CRT 镜片和 12 例接受 LASIK 治疗的患者的病历。每位患者在治疗前后均记录未矫正视力（UCVA）、最佳矫正视力（BSCVA）、角膜屈光度和光学高阶像差。
CRT 组 11 例患者（4 男，7 女），平均年龄 29.1+/-5.2 岁（23 至 40 岁），LASIK 组 12 例患者（3 男，9 女），平均年龄 39.2+/-12.0 岁（23 至 60 岁）。CRT 治疗 1 个月后，患者的角膜屈光度从基线时的-2.81+/-1.05 屈光度（D）显著下降至-0.77+/-0.64 D（P<.0001），LASIK 治疗 1 个月后，患者的角膜屈光度从基线时的-3.11+/-1.21 D 下降至-0.43+/-0.27 D（P<.0001）。CRT 和 LASIK 治疗 4mm 瞳孔时，总高阶像差均无显著变化，但 6mm 瞳孔时总高阶像差显著增加。CRT 和 LASIK 治疗 6mm 瞳孔时，总高阶像差和彗差的变化因素均具有统计学意义。CRT 治疗 6mm 瞳孔时，球差的增加因素具有统计学意义（P=.01）。
角膜接触镜屈光治疗和 LASIK 均可有效矫正近视，但均会导致 6mm 瞳孔高阶像差增加，增加程度相似。然而，CRT 治疗后球差明显大于 LASIK 治疗。
