帕金森病患者和正常人脑内新型内源性胺类物质2-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉和1,2-二甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的存在情况。
Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.
作者信息
Niwa T, Takeda N, Yoshizumi H, Tatematsu A, Yoshida M, Dostert P, Naoi M, Nagatsu T
机构信息
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
出版信息
Biochem Biophys Res Commun. 1991 Jun 14;177(2):603-9. doi: 10.1016/0006-291x(91)91831-v.
2-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline were identified for the first time as novel endogenous amines in parkinsonian and normal human brains by gas chromatography-mass spectrometry. It is of interest that these tetrahydroisoquinolines are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which produces Parkinson's disease.
通过气相色谱 - 质谱联用技术，首次在帕金森病患者和正常人脑中鉴定出2 - 甲基 - 6,7 - 二羟基 - 1,2,3,4 - 四氢异喹啉和1,2 - 二甲基 - 6,7 - 二羟基 - 1,2,3,4 - 四氢异喹啉为新型内源性胺类物质。有趣的是，这些四氢异喹啉是可引发帕金森病的1 - 甲基 - 4 - 苯基 - 1,2,3,6 - 四氢吡啶（MPTP）的类似物。
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