Kajita M, Niwa T, Fujisaki M, Ueki M, Niimura K, Sato M, Egami K, Naoi M, Yoshida M, Nagatsu T
Nagoya University Branch Hospital, Japan.
J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):345-51. doi: 10.1016/0378-4347(95)00106-s.
1-Phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline were detected for the first time in parkinsonian human brain using gas chromatography-tandem mass spectrometry (GC-MS-MS). Since these compounds are structural analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that produces parkinsonism in humans, they might be candidates for endogenous MPTP-like neurotoxins.
使用气相色谱-串联质谱法（GC-MS-MS）首次在帕金森病患者大脑中检测到1-苯基-N-甲基-1,2,3,4-四氢异喹啉和1-苯基-1,2,3,4-四氢异喹啉。由于这些化合物是在人类中产生帕金森综合征的1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的结构类似物，它们可能是内源性MPTP样神经毒素的候选物。
