四氢异喹啉和1-甲基-四氢异喹啉作为大鼠脑中新型内源性胺类物质。
Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain.
作者信息
Kohno M, Ohta S, Hirobe M
出版信息
Biochem Biophys Res Commun. 1986 Oct 15;140(1):448-54. doi: 10.1016/0006-291x(86)91111-3.
PMID:3778459
Abstract
This is the first report to identify 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain. The detection was performed by coupled gas chromatography - multiple ion detection, using heptafluorobutyric anhydride and pentafluoropropionic anhydride as derivatizing reagents. These amines might be endogenous substances inducing parkinsonism.
摘要
这是首份鉴定出1,2,3,4-四氢异喹啉和1-甲基-1,2,3,4-四氢异喹啉为未处理大鼠脑内源性胺类的报告。检测采用气相色谱-多离子检测联用，使用七氟丁酸酐和五氟丙酸酐作为衍生试剂。这些胺类可能是诱发帕金森症的内源性物质。
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