Kohno M, Ohta S, Hirobe M
Biochem Biophys Res Commun. 1986 Oct 15;140(1):448-54. doi: 10.1016/0006-291x(86)91111-3.
This is the first report to identify 1,2,3,4-tetrahydroisoquinoline and 1-methyl-1,2,3,4-tetrahydroisoquinoline as endogenous amines from non-treated rat brain. The detection was performed by coupled gas chromatography - multiple ion detection, using heptafluorobutyric anhydride and pentafluoropropionic anhydride as derivatizing reagents. These amines might be endogenous substances inducing parkinsonism.
这是首份鉴定出1,2,3,4-四氢异喹啉和1-甲基-1,2,3,4-四氢异喹啉为未处理大鼠脑内源性胺类的报告。检测采用气相色谱-多离子检测联用，使用七氟丁酸酐和五氟丙酸酐作为衍生试剂。这些胺类可能是诱发帕金森症的内源性物质。
