Alavian Seyed-Moayed, Kabir Ali, Ahmadi Amir Bahrami, Lankarani Kamran Bagheri, Shahbabaie Mohammad Ali, Ahmadzad-Asl Masoud
Department of Gastroenterology and Hepatology, Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Hemodial Int. 2010 Jul;14(3):253-62. doi: 10.1111/j.1542-4758.2010.00437.x. Epub 2010 May 17.
Hemodialysis (HD) patients are recognized as one of the high-risk groups for hepatitis C virus (HCV) infection. The prevalence of HCV infection varies widely between 5.5% and 24% among different Iranian populations. Preventive programs for reducing HCV infection prevalence in these patients require accurate information. In the present study, we estimated HCV infection prevalence in Iranian HD patients. In this systematic review, we collected all published and unpublished documents related to HCV infection prevalence in Iranian HD patients from April 2001 to March 2008. We selected descriptive/analytic cross-sectional studies/surveys that have sufficiently declared objectives, a proper sampling method with identical and valid measurement instruments for all study subjects, and proper analysis methods regarding sampling design and demographic adjustments. We used a meta-analysis method to calculate nationwide prevalence estimation. Eighteen studies from 12 provinces (consisting 49.02% of the Iranian total population) reported the prevalence of HCV infection in Iranian HD patients. The HCV infection prevalence in Iranian HD patients is 7.61% (95% confidence interval: 6.06-9.16%) with the recombinant immunoblot assay method. Iran is among countries with low HCV infection prevalence in HD patients.
血液透析（HD）患者被认为是丙型肝炎病毒（HCV）感染的高危群体之一。在不同的伊朗人群中，HCV感染率差异很大，在5.5%至24%之间。降低这些患者中HCV感染率的预防项目需要准确的信息。在本研究中，我们估计了伊朗HD患者的HCV感染率。在这项系统评价中，我们收集了2001年4月至2008年3月期间所有已发表和未发表的与伊朗HD患者HCV感染率相关的文献。我们选择了描述性/分析性横断面研究/调查，这些研究有充分明确的目标、对所有研究对象采用相同且有效的测量工具的适当抽样方法，以及关于抽样设计和人口统计学调整的适当分析方法。我们使用荟萃分析方法来计算全国范围内患病率估计值。来自12个省份（占伊朗总人口的49.02%）的18项研究报告了伊朗HD患者的HCV感染率。采用重组免疫印迹法时，伊朗HD患者的HCV感染率为7.61%（95%置信区间：6.06 - 9.16%）。伊朗是HD患者中HCV感染率较低的国家之一。
