来自远东海星多棘海盘车的海星皂苷及其抗癌活性。
Asterosaponins from the Far Eastern starfish Leptasterias ochotensis and their anticancer activity.
作者信息
Malyarenko Timofey V, Kicha Alla A, Ivanchina Natalia V, Kalinovsky Anatoly I, Popov Roman S, Vishchuk Olesya S, Stonik Valentin A
机构信息
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Pr. 100-let Vladivostoku 159, 690022 Vladivostok, Russia.
出版信息
Steroids. 2014 Sep;87:119-27. doi: 10.1016/j.steroids.2014.05.027. Epub 2014 Jun 11.
Six new asterosaponins, leptasteriosides A-F (3-8), one new and one previously known asterogenins (1, 2) were isolated from the alcoholic extract of the Far Eastern starfish Leptasterias ochotensis. The structures of 1-8 were elucidated by extensive NMR and ESI-MS techniques. Compounds 2-8 showed slight or moderate cytotoxic activities against cancer cell lines RPMI-7951 and T-47D. The asterosaponins 3-5 demonstrated a significant inhibition of RPMI-7951 and T-47D cell colony formation in soft agar clonogenic assay in nontoxic doses.
从远东海星多棘海盘车（Leptasterias ochotensis）的乙醇提取物中分离出6种新的海星皂苷，即多棘海盘车皂苷A - F（3 - 8），1种新的和1种已知的海星苷元（1, 2）。通过广泛的核磁共振（NMR）和电喷雾电离质谱（ESI - MS）技术阐明了1 - 8的结构。化合物2 - 8对癌细胞系RPMI - 7951和T - 47D表现出轻微或中等的细胞毒性活性。在无毒剂量下，海星皂苷3 - 5在软琼脂克隆形成试验中对RPMI - 7951和T - 47D细胞集落形成有显著抑制作用。
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