人成纤维细胞对I型、II型和III型胶原蛋白以及胶原蛋白衍生肽的趋化吸引作用。
Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides.
作者信息
Postlethwaite A E, Seyer J M, Kang A H
出版信息
Proc Natl Acad Sci U S A. 1978 Feb;75(2):871-5. doi: 10.1073/pnas.75.2.871.
Abstract
The chemotactice response of human dermal fibroblasts of type I, II, and III human collagens and collagen-derived peptides was quantitated by an in vitro assay. All three native human collagens and constituent alpha chains can serve as chemoattractants for fibroblasts in vitro. When type I, II, and III collagens were digested by bacterial collagenase, the resulting peptides were also chemotactic. In addition, synthetic di- and tripeptides containing hydroxyproline were also chemotactic for fibroblasts. Since collagen is degraded and remodeled at sites of tissue injury and inflammation, these findings suggest that collagen and collagen-degradation peptides might function as chemotactic stimuli for fibroblasts in vivo and attract these cells to effect repair of damaged tissue.
摘要
通过体外试验对人I型、II型和III型胶原蛋白及胶原蛋白衍生肽刺激人皮肤成纤维细胞的趋化反应进行了定量分析。所有这三种天然人胶原蛋白及其组成的α链在体外均可作为成纤维细胞的化学引诱剂。当I型、II型和III型胶原蛋白被细菌胶原酶消化后，所产生的肽也具有趋化作用。此外，含羟脯氨酸的合成二肽和三肽对成纤维细胞也有趋化作用。由于胶原蛋白在组织损伤和炎症部位会发生降解和重塑，这些发现表明胶原蛋白和胶原蛋白降解肽在体内可能作为成纤维细胞的趋化刺激物，吸引这些细胞来修复受损组织。
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本文引用的文献
1
A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.一种用于光度法测定氨基酸及相关化合物的改良茚三酮试剂。
J Biol Chem. 1954 Dec;211(2):907-13.
2
Characterization of the alpha-chains of chick skin collagen and the nature of the NH2-terminal cross-link region.鸡皮肤胶原蛋白α链的表征及氨基末端交联区域的性质
Biochemistry. 1969 Sep;8(9):3648-55. doi: 10.1021/bi00837a023.
3
Characterization of the cyanogen bromide peptides from the alpha-2 chain of chick skin collagen.鸡皮肤胶原蛋白α-2链溴化氰肽段的特性分析
Biochemistry. 1969 Aug;8(8):3200-4. doi: 10.1021/bi00836a011.
4
Characterization of the cyanogen bromide peptides from the alpha 1 chain of chick skin collagen.鸡皮肤胶原蛋白α1链溴化氰肽段的特性分析
Biochemistry. 1969 Apr;8(4):1506-14. doi: 10.1021/bi00832a029.
5
Isolation and characterization of the cyanogen bromide peptides from the l(II) chain of chick cartilage collagen.鸡软骨胶原蛋白l(II)链溴化氰肽的分离与鉴定
Biochemistry. 1971 Aug 3;10(16):3030-5. doi: 10.1021/bi00792a007.
6
Collagen heterogeneity. High resolution separation of native ( 1(I) 2 2 and ( 1(II) 3 and their component chains.胶原蛋白异质性。天然（1(I)22和(1(II)3及其组成链的高分辨率分离。
J Biol Chem. 1972 Oct 25;247(20):6469-73.
7
Isolation and characterization of cyanogen bromide peptides from basement membrane collagen.从基底膜胶原蛋白中分离和鉴定溴化氰肽
Biochem Biophys Res Commun. 1972 Jun 9;47(5):1151-8. doi: 10.1016/0006-291x(72)90955-2.
8
Isolation of a collagen from basement membranes containing three identical - chains.从含有三条相同α链的基底膜中分离出一种胶原蛋白。
Biochem Biophys Res Commun. 1971 Oct 1;45(1):226-34. doi: 10.1016/0006-291x(71)90073-8.
9
Collagen polymorphism: characterization of molecules with the chain composition (alpha 1 (3)03 in human tissues.胶原蛋白多态性：人体组织中具有链组成（α1(3)03）的分子的特征
Science. 1974 Mar;183(130):1200-1. doi: 10.1126/science.183.4130.1200.
10
Human aorta collagens: evidence for three distinct species.人主动脉胶原蛋白：三种不同类型的证据。
Biochem Biophys Res Commun. 1974 Apr 8;57(3):717-25. doi: 10.1016/0006-291x(74)90605-6.
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