Elango Jeevithan, Zamora-Ledezma Camilo, Ge Baolin, Hou Chunyu, Pan Zhilin, Bao Bin, Pérez Albacete Martínez Carlos, Granero Marín José Manuel, de Val José Eduardo Maté Sánchez, Bao Chunling, Wu Wenhui
Department of Biomaterials Engineering, Faculty of Health Sciences, UCAM-Universidad Católica San Antonio de Murcia, Guadalupe, 30107 Murcia, Spain.
Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Bioengineering (Basel). 2022 Jul 15;9(7):321. doi: 10.3390/bioengineering9070321.
In biology, collagen-biomaterial regulates several signaling mechanisms of bone and immune cells involved in tissue repair and any imbalance in collagen turnover may affect the homeostasis of cells, becoming a major cause of several complications. In this case, the administration of oral collagen may play a potential role in returning cells to their normal function. For several decades, the beneficial effects of collagen have been explored widely, and thus many commercial products are available in cosmetics, food, and biomedical fields. For instance, collagen-based-products have been widely used to treat the complications of cartilage-related-disorders. Many researchers are reporting the anti-arthritogenic properties of collagen-based materials. In contrast, collagen, especially type-II collagen (CII), has been widely used to induce arthritis by immunization in an animal-model with or without adjuvants, and the potentially immunogenic-properties of collagen have been continuously reported for a long time. Additionally, the immune tolerance of collagen is mainly regulated by the T-lymphocytes and B-cells. This controversial hypothesis is getting more and more evidence nowadays from both sides to support its mechanism. Therefore, this review links the gap between the arthritogenic and anti-arthritogenic effects of collagen and explored the actual mechanism to understand the fundamental concept of collagen in arthritis. Accordingly, this review opens-up several unrevealed scientific knots of collagen and arthritis and helps the researchers understand the potential use of collagen in therapeutic applications.
在生物学中，胶原蛋白生物材料调节参与组织修复的骨骼和免疫细胞的多种信号传导机制，胶原蛋白周转的任何失衡都可能影响细胞的稳态，成为多种并发症的主要原因。在这种情况下，口服胶原蛋白的给药可能在使细胞恢复正常功能方面发挥潜在作用。几十年来，人们广泛探索了胶原蛋白的有益作用，因此在化妆品、食品和生物医学领域有许多商业产品可供使用。例如，基于胶原蛋白的产品已被广泛用于治疗软骨相关疾病的并发症。许多研究人员报告了基于胶原蛋白的材料的抗关节炎特性。相比之下，胶原蛋白，尤其是II型胶原蛋白（CII），已被广泛用于在有或没有佐剂的动物模型中通过免疫诱导关节炎，并且胶原蛋白的潜在免疫原性特性长期以来一直被不断报道。此外，胶原蛋白的免疫耐受性主要由T淋巴细胞和B细胞调节。如今，这个有争议的假设越来越多地从双方获得证据来支持其机制。因此，本综述弥合了胶原蛋白的致关节炎和抗关节炎作用之间的差距，并探索了实际机制以理解胶原蛋白在关节炎中的基本概念。据此，本综述解开了几个关于胶原蛋白和关节炎未揭示的科学谜团，并帮助研究人员了解胶原蛋白在治疗应用中的潜在用途。
