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丙酮酸乙酯可下调脂多糖刺激的犬外周血单个核细胞中肿瘤坏死因子α和白细胞介素（IL）-6的表达，并上调IL-10的表达。

Ethyl pyruvate downregulates tumor necrosis factor alpha and interleukin (IL)-6 and upregulates IL-10 in lipopolysaccharide-stimulated canine peripheral blood mononuclear cells.

作者信息

Yu Do-Hyeon, Noh Dong-Ho, Song Ru-Hui, Park Jinho

机构信息

College of Veterinary Medicine & Bio-Safety Research Institute, Chonbuk National University, Jeonju, Jeonbuk, South Korea.

出版信息

J Vet Med Sci. 2010 Oct;72(10):1379-81. doi: 10.1292/jvms.09-0590. Epub 2010 May 21.

DOI:10.1292/jvms.09-0590
PMID:20495301
Abstract

We investigated the anti-inflammatory effects of ethyl pyruvate (EP) on LPS-stimulated canine PBMCs in vitro. We found that EP treatment inhibited the mRNA expressions of proinflammatory cytokines (TNF-α and IL-6), but induced mRNA expression of anti-inflammatory cytokines (IL-10). ELISA measurements revealed that EP also effectively downregulates the LPS-induced increase in proinflammatory cytokine release, while upregulating anti-inflammatory cytokine release. These data indicate that EP could be an effective anti-inflammatory agent in dogs.

摘要

我们在体外研究了丙酮酸乙酯（EP）对脂多糖（LPS）刺激的犬外周血单个核细胞（PBMCs）的抗炎作用。我们发现，EP处理可抑制促炎细胞因子（TNF-α和IL-6）的mRNA表达，但可诱导抗炎细胞因子（IL-10）的mRNA表达。酶联免疫吸附测定（ELISA）结果显示，EP还能有效下调LPS诱导的促炎细胞因子释放增加，同时上调抗炎细胞因子释放。这些数据表明，EP可能是犬类有效的抗炎剂。

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