Oxidative Stress and Exercise Biochemistry Laboratory, Department of Physical Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand, 50200.
J Int Soc Sports Nutr. 2010 May 26;7:21. doi: 10.1186/1550-2783-7-21.
The aim of this study was to evaluate the effects of Vernonia cinerea Less. (VC) supplementation and exercise on oxidative stress biomarkers, beta-endorphin release, and the rate of cigarette smoking.
Volunteer smokers were randomly divided into four groups: group 1: VC supplement; group 2: exercise with VC supplement; group 3: exercise; and group 4: control. VC was prepared by wash and dry techniques and taken orally before smoking, matching the frequency of strenuous exercise (three times weekly). Before and after a two month period, exhaled carbon monoxide (CO), blood oxidative stress (malondialdehyde [MDA], nitric oxide [NOx], protein hydroperoxide [PrOOH] and total antioxidant capacity [TAC]), beta-endorphin and smoking rate were measured, and statistically analyzed.
In Group 1, MDA, PrOOH, and NOx significantly decreased, whereas TAC increased (p < 0.05). In Group 2, MDA and PrOOH decreased (p < 0.05), with no other changes noted (p > 0.05). In Group 3, MDA, PrOOH, NOx, TAC, and beta-endorphin levels increased significantly (p < 0.05). Group 4 showed no change in oxidative stress variables or beta-endorphine levels (p > 0.05). All groups had lower levels of CO after the intervention. The smoking rate for light cigarette decreased in group 2(62.7%), 1(59.52%), 3 (53.57%) and 4(14.04%), whereas in self-rolled cigarettes it decreased in group 1 (54.47%), 3 (42.30%), 2 (40%) and 4 (9.2%).
Supplementation with Vernonia cinerea Less and exercise provided benefit related to reduced smoking rate, which may be related to oxidaive stress and beta-endorphine levels.
本研究旨在评估 Vernonia cinerea Less.（VC）补充剂和运动对氧化应激生物标志物、β-内啡肽释放和吸烟率的影响。
志愿吸烟者被随机分为四组：第 1 组：VC 补充剂；第 2 组：VC 补充剂加运动；第 3 组：运动；第 4 组：对照组。VC 采用洗涤干燥技术制备，在吸烟前口服，与剧烈运动（每周三次）的频率相匹配。在为期两个月的时间前后，测量呼气一氧化碳（CO）、血液氧化应激（丙二醛[MDA]、一氧化氮[NOx]、蛋白质过氧化物[PrOOH]和总抗氧化能力[TAC]）、β-内啡肽和吸烟率，并进行统计学分析。
第 1 组 MDA、PrOOH 和 NOx 显著降低，而 TAC 增加（p<0.05）。第 2 组 MDA 和 PrOOH 降低（p<0.05），其他无变化（p>0.05）。第 3 组 MDA、PrOOH、NOx、TAC 和β-内啡肽水平显著增加（p<0.05）。第 4 组氧化应激变量或β-内啡肽水平无变化（p>0.05）。所有组干预后 CO 水平均降低。第 2 组（62.7%）、第 1 组（59.52%）、第 3 组（53.57%）和第 4 组（14.04%）轻烟吸烟率降低，而第 1 组（54.47%）、第 3 组（42.30%）、第 2 组（40%）和第 4 组（9.2%）自卷香烟吸烟率降低。
Vernonia cinerea Less 补充剂和运动有助于降低吸烟率，这可能与氧化应激和β-内啡肽水平有关。
