Skovlund E, Fyllingen G, Landre H, Nesheim B I
Department of Informatics, University of Oslo, Norway.
Eur J Clin Pharmacol. 1991;40(4):343-7. doi: 10.1007/BF00265841.
A new sequential test has been used to compare the effect of paracetamol and placebo on uterine cramping. Paracetamol was significantly superior to placebo at the 5% level. 75 patients were included in the trial, whereas in a fixed sample study 90 patients would have been required to obtain the same significance level and power. The magnitude of the difference in treatment effect was estimated following the sequential test. In addition to the effect on uterine pain, which was the primary variable, the effect on episiotomy pain was also estimated. Paracetamol was also superior to placebo against the episiotomy pain.
一种新的序贯检验已被用于比较对乙酰氨基酚和安慰剂对子宫绞痛的影响。在5%的显著水平上，对乙酰氨基酚显著优于安慰剂。该试验纳入了75名患者，而在固定样本研究中，要获得相同的显著水平和检验效能则需要90名患者。序贯检验后估计了治疗效果差异的大小。除了对作为主要变量的子宫疼痛的影响外，还估计了对会阴切开术疼痛的影响。在缓解会阴切开术疼痛方面，对乙酰氨基酚也优于安慰剂。
