Castañeda P, Gómez L, Mata R, Lotina-Hennsen B, Anaya A L, Bye R
Departamento de Farmacia, Instituto de Química, Mexico.
J Nat Prod. 1996 Mar;59(3):323-6. doi: 10.1021/np960199m.
Investigation on the roots of Helianthella quinquenervis (Hook.) A. Gray (Asteraceae), led to the isolation of one new benzofuran (6-methoxy-tremetone (1)) and a new prenylacetophenone (4-beta-D-(glucopyranosyloxy)-3-[3-methoxy-trans-isopenten-1 -yl] acetophenone (3)). In addition, 6-hydroxy-3-methoxytremetone (2), encecalin (6), euparin (5), demethylencecalin (4), and angelic acid were obtained. Structural assignments of the isolated compounds were based on spectroscopic and spectrometric analysis. Natural products 1-4 showed marginal cytotoxicity against three human tumor cell lines [MCF-7, A-549, and HT-29]. Compounds 4 and 6 inhibited the radicle growth of Amaranthus hypochondriacus and Echinochloa crusgalli. Furthermore, substances 4-6 exhibited antifungal activity against Trichophyton mentagrophytes.
对五脉金光菊（菊科）根的研究，导致分离出一种新的苯并呋喃（6-甲氧基-震颤酮（1））和一种新的异戊烯基苯乙酮（4-β-D-（吡喃葡萄糖氧基）-3-[3-甲氧基-反式-异戊烯-1-基]苯乙酮（3））。此外，还得到了6-羟基-3-甲氧基震颤酮（2）、恩卡林（6）、优帕因（5）、去甲基恩卡林（4）和当归酸。分离出的化合物的结构归属基于光谱和光谱分析。天然产物1-4对三种人类肿瘤细胞系[MCF-7、A-549和HT-29]显示出轻微的细胞毒性。化合物4和6抑制了苋属植物和稗草的胚根生长。此外，物质4-6对须癣毛癣菌表现出抗真菌活性。
