Koo W W, Poh D, Leong M, Tam Y K, Succop P, Checkland E G
Department of Pediatrics, University of Alberta, Edmonton, Canada.
JPEN J Parenter Enteral Nutr. 1991 Mar-Apr;15(2):144-7. doi: 10.1177/0148607191015002144.
Glucose polymer is a carbohydrate source with variable chain lengths of glucose units which may result in variable osmolality. The osmolality of two commercial glucose polymers was measured in reconstituted powder infant formulas, and the change in osmolality of infant milk formulas at the same increases in energy density (67 kcal/dL to 81 and 97 kcal/dL) from the use of additional milk powder or glucose polymers was compared. All samples were prepared from powders (to nearest 0.1 mg), and osmolality was measured by freezing point depression. For both glucose polymers the within-batch variability of the measured osmolality was less than 3.5%, and between-batch variability of the measured osmolality was less than 9.6%. The measured osmolality varies linearly with energy density (p less than 0.001) and was highest in infant formula reconstituted from milk powder alone. However, there exist significant differences in the measured osmolality between different glucose polymer preparations. At high energy densities (greater than or equal to 97 kcal/dL), infant milk formulas prepared with milk powder alone or with the addition of certain glucose polymer preparation may have high osmolality (greater than or equal to 450 mosm/kg) and theoretically predispose the infant to complications of hyperosmotic feeds.
葡萄糖聚合物是一种碳水化合物来源，其葡萄糖单元的链长可变，这可能导致渗透压可变。在重构的粉状婴儿配方奶粉中测量了两种商业葡萄糖聚合物的渗透压，并比较了在能量密度相同增加量（从67千卡/分升增加到81和97千卡/分升）时，使用额外奶粉或葡萄糖聚合物的婴儿配方奶粉渗透压的变化。所有样品均由粉末制备（精确到最接近的0.1毫克），并通过冰点降低法测量渗透压。对于两种葡萄糖聚合物，测量渗透压的批内变异性小于3.5%，批间变异性小于9.6%。测量的渗透压与能量密度呈线性变化（p小于0.001），并且在仅由奶粉重构的婴儿配方奶粉中最高。然而，不同葡萄糖聚合物制剂之间的测量渗透压存在显著差异。在高能量密度（大于或等于97千卡/分升）时，仅用奶粉或添加某些葡萄糖聚合物制剂制备的婴儿配方奶粉可能具有高渗透压（大于或等于450毫渗摩尔/千克），并且理论上会使婴儿易患高渗性喂养并发症。
