qnrVC 样基因位于一种新型复合 1 类整合子中，该整合子中含有 ISCR1 元件，其宿主为来自中国山东省水生环境的气单胞菌属菌株。
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.
机构信息
The State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, 27 Shanda Nanlu, Jinan 250100, Shandong, People's Republic of China.
出版信息
Antimicrob Agents Chemother. 2010 Aug;54(8):3471-4. doi: 10.1128/AAC.01668-09. Epub 2010 Jun 1.
Abstract
A qnrVC-like gene, qnrVC4, was found in a novel complex class 1 integron gene cassette array following the ISCR1 element and bla(PER-1) in a multidrug-resistant strain of the aquatic bacterium Aeromonas punctata. The deduced QnrVC4 protein sequence shares 45% to 81% amino acid identity with quinolone resistance determinants QnrB6, QnrA1, QnrS1, QnrC, QnrVC1, and QnrVC3. A Ser-83 to Ile amino acid substitution in gyrase A may be mainly responsible for ciprofloxacin resistance in this strain.
摘要
在一种耐多药的水生细菌豚鼠气单胞菌中，发现了一个 qnrVC-like 基因，qnrVC4，它位于 ISCR1 元件和 bla(PER-1) 之后的新型复合 1 类整合子基因盒阵列中。推导的 QnrVC4 蛋白序列与喹诺酮类耐药决定簇 QnrB6、QnrA1、QnrS1、QnrC、QnrVC1 和 QnrVC3 具有 45%至 81%的氨基酸同一性。gyrase A 中的丝氨酸-83 到异亮氨酸的氨基酸取代可能是该菌株对环丙沙星耐药的主要原因。
相似文献
1
qnrVC-like gene located in a novel complex class 1 integron harboring the ISCR1 element in an Aeromonas punctata strain from an aquatic environment in Shandong Province, China.qnrVC 样基因位于一种新型复合 1 类整合子中，该整合子中含有 ISCR1 元件，其宿主为来自中国山东省水生环境的气单胞菌属菌株。
Antimicrob Agents Chemother. 2010 Aug;54(8):3471-4. doi: 10.1128/AAC.01668-09. Epub 2010 Jun 1.
2
Identification of an integron containing the quinolone resistance gene qnrA1 in Shewanella xiamenensis.在厦门希瓦氏菌中鉴定出一个含有喹诺酮抗性基因qnrA1的整合子。
FEMS Microbiol Lett. 2015 Sep;362(18):fnv146. doi: 10.1093/femsle/fnv146. Epub 2015 Aug 26.
3
Incidence of antimicrobial resistance genes and class 1 integron gene cassettes in multidrug-resistant motile Aeromonas sp. isolated from ornamental guppy (Poecilia reticulata).从观赏孔雀鱼（孔雀鱼）分离出的多重耐药运动性气单胞菌中抗菌抗性基因和1类整合子基因盒的发生率。
Lett Appl Microbiol. 2019 Jul;69(1):2-10. doi: 10.1111/lam.13162. Epub 2019 May 2.
4
Analysis of plasmid-mediated multidrug resistance in Escherichia coli and Klebsiella oxytoca isolates from clinical specimens in Japan.日本临床标本中分离的大肠杆菌和产酸克雷伯菌的质粒介导多重耐药性分析。
Int J Antimicrob Agents. 2009 Oct;34(4):347-50. doi: 10.1016/j.ijantimicag.2009.05.007. Epub 2009 Jun 27.
5
Multidrug resistant Aeromonas spp. isolated from zebrafish (Danio rerio): antibiogram, antimicrobial resistance genes and class 1 integron gene cassettes.从斑马鱼（Danio rerio）中分离出的多重耐药气单胞菌属：抗菌谱、抗菌耐药基因和1类整合子基因盒
Lett Appl Microbiol. 2019 May;68(5):370-377. doi: 10.1111/lam.13138. Epub 2019 Mar 19.
6
Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp.环境气单胞菌属中意外出现质粒介导的喹诺酮耐药决定子
Emerg Infect Dis. 2008 Feb;14(2):231-7. doi: 10.3201/eid1402.070677.
7
High Prevalence of Plasmid-Mediated Quinolone Resistance and IncQ Plasmids Carrying qnrS2 Gene in Bacteria from Rivers near Hospitals and Aquaculture in China.中国医院及水产养殖附近河流细菌中质粒介导喹诺酮耐药性及携带qnrS2基因的IncQ质粒的高流行率
PLoS One. 2016 Jul 18;11(7):e0159418. doi: 10.1371/journal.pone.0159418. eCollection 2016.
8
Distribution of Antimicrobial Resistance Genes and Class 1 Integron Gene Cassette Arrays in Motile Aeromonas spp. Isolated from Goldfish (Carassius auratus).从金鱼（Carassius auratus）分离的运动气单胞菌属中抗菌抗性基因和1类整合子基因盒阵列的分布
Microb Drug Resist. 2018 Oct;24(8):1217-1225. doi: 10.1089/mdr.2017.0388. Epub 2018 Feb 8.
9
Characterization of antimicrobial resistance in Klebsiella species isolated from chicken broilers.从肉鸡中分离出的克雷伯氏菌属细菌的抗菌药物耐药性特征分析。
Int J Food Microbiol. 2016 Sep 2;232:95-102. doi: 10.1016/j.ijfoodmicro.2016.06.001. Epub 2016 Jun 3.
10
Mechanisms of quinolone resistance in Aeromonas species isolated from humans, water and eels.从人类、水和鳗鱼中分离的气单胞菌属细菌对喹诺酮类药物耐药的机制。
Res Microbiol. 2010 Jan-Feb;161(1):40-5. doi: 10.1016/j.resmic.2009.10.006. Epub 2009 Nov 10.
引用本文的文献
1
Species Diversity, Virulence Characteristics, and Antimicrobial Susceptibility Patterns in Village Freshwater Aquaculture Ponds in North India.印度北部乡村淡水养殖池塘中的物种多样性、毒力特征及药敏模式
Antibiotics (Basel). 2025 Mar 12;14(3):294. doi: 10.3390/antibiotics14030294.
2
Novel Qnr Families as Conserved and Intrinsic Quinolone Resistance Determinants in spp.新型 Qnr 家族作为 spp. 中保守且固有喹诺酮类耐药决定因素
J Microbiol Biotechnol. 2024 Jun 28;34(6):1276-1286. doi: 10.4014/jmb.2403.03043. Epub 2024 Apr 19.
3
Metagenomic Analysis of the Abundance and Composition of Antibiotic Resistance Genes in Hospital Wastewater in Benin, Burkina Faso, and Finland.贝宁、布基纳法索和芬兰医院废水中抗生素耐药基因的丰度和组成的宏基因组分析。
mSphere. 2023 Feb 21;8(1):e0053822. doi: 10.1128/msphere.00538-22. Epub 2023 Feb 2.
4
Integron Functionality and Genome Innovation: An Update on the Subtle and Smart Strategy of Integrase and Gene Cassette Expression Regulation.整合子功能与基因组创新：整合酶及基因盒表达调控的精妙策略新进展
Microorganisms. 2022 Jan 20;10(2):224. doi: 10.3390/microorganisms10020224.
5
Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain.环境在抗菌药物耐药性（AMR）通过食物链出现和传播过程中所起的作用。
EFSA J. 2021 Jun 17;19(6):e06651. doi: 10.2903/j.efsa.2021.6651. eCollection 2021 Jun.
6
Extensively drug-resistant IMP-16-producing Pseudomonas monteilii isolated from cerebrospinal fluid.从脑脊液中分离到广泛耐药的IMP-16 型产金属β-内酰胺酶假单胞菌
Infect Genet Evol. 2021 Jan;87:104658. doi: 10.1016/j.meegid.2020.104658. Epub 2020 Nov 30.
7
Transferable Mechanisms of Quinolone Resistance from 1998 Onward.1998 年以来喹诺酮类耐药的可转移机制。
Clin Microbiol Rev. 2019 Aug 14;32(4). doi: 10.1128/CMR.00007-19. Print 2019 Sep 18.
8
Plasmid-mediated fluoroquinolone resistance associated with extra-intestinal isolates from hospital samples.质粒介导的氟喹诺酮耐药与来自医院样本的肠道外分离株有关。
Indian J Med Res. 2019 Feb;149(2):192-198. doi: 10.4103/ijmr.IJMR_2092_17.
9
Computational discovery and functional validation of novel fluoroquinolone resistance genes in public metagenomic data sets.公共宏基因组数据集中新型氟喹诺酮耐药基因的计算发现与功能验证
BMC Genomics. 2017 Sep 2;18(1):682. doi: 10.1186/s12864-017-4064-0.
10
Plasmid-Mediated Quinolone Resistance (PMQR) Genes and Class 1 Integrons in Quinolone-Resistant Marine Bacteria and Clinical Isolates of Escherichia coli from an Aquacultural Area.质粒介导的喹诺酮类耐药基因（PMQR）和 1 类整合子在水产养殖区喹诺酮类耐药海洋细菌和大肠杆菌临床分离株中的分布。
Microb Ecol. 2018 Jan;75(1):104-112. doi: 10.1007/s00248-017-1016-9. Epub 2017 Jun 23.
本文引用的文献
1
Inverse correlation between promoter strength and excision activity in class 1 integrons.在 class 1 整合子中，启动子强度与切除活性呈负相关。
PLoS Genet. 2010 Jan;6(1):e1000793. doi: 10.1371/journal.pgen.1000793. Epub 2010 Jan 8.
2
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.从观赏鱼及其携带水中分离出的耐多药细菌及其相关抗菌药物耐药基因的高流行率。
PLoS One. 2009 Dec 21;4(12):e8388. doi: 10.1371/journal.pone.0008388.
3
New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis.在奇异变形杆菌临床分离株中发现新型质粒介导的喹诺酮耐药基因qnrC。
Antimicrob Agents Chemother. 2009 May;53(5):1892-7. doi: 10.1128/AAC.01400-08. Epub 2009 Mar 2.
4
qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin.qnrD，一种在人类源肠炎沙门氏菌肯塔基血清型和牛败血菌株中赋予可转移喹诺酮耐药性的新基因。
Antimicrob Agents Chemother. 2009 Feb;53(2):603-8. doi: 10.1128/AAC.00997-08. Epub 2008 Nov 24.
5
Molecular diversity of class 1 integrons in human isolates of Aeromonas spp. from southern Taiwan.来自台湾南部气单胞菌属人类分离株中1类整合子的分子多样性
Jpn J Infect Dis. 2008 Sep;61(5):343-9.
6
Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake.从瑞士湖泊中分离出的嗜糖气单胞菌中质粒介导的喹诺酮耐药性
J Antimicrob Chemother. 2008 Nov;62(5):948-50. doi: 10.1093/jac/dkn341. Epub 2008 Sep 3.
7
New qnr gene cassettes associated with superintegron repeats in Vibrio cholerae O1.与霍乱弧菌O1型超整合子重复序列相关的新型qnr基因盒
Emerg Infect Dis. 2008 Jul;14(7):1129-31. doi: 10.3201/eid1407.080132.
8
qnr Gene nomenclature.qnr基因命名法。
Antimicrob Agents Chemother. 2008 Jul;52(7):2297-9. doi: 10.1128/AAC.00147-08. Epub 2008 Apr 21.
9
Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp.环境气单胞菌属中意外出现质粒介导的喹诺酮耐药决定子
Emerg Infect Dis. 2008 Feb;14(2):231-7. doi: 10.3201/eid1402.070677.
10
Molecular characterization of class 3 integrons from Delftia spp.代尔夫特菌属3类整合子的分子特征分析
J Bacteriol. 2007 Sep;189(17):6276-83. doi: 10.1128/JB.00348-07. Epub 2007 Jun 15.
Zotero 插件