Department of Internal Medicine, Hematology-Oncology, University of Cologne, Joseph-Stelzmanstrasse 9, Cologne, Germany.
Nat Rev Clin Oncol. 2010 Jun;7(6):301-2. doi: 10.1038/nrclinonc.2010.71.
Prognostic models for patients with Hodgkin lymphoma are imperfect and do not allow a precise individualized therapy. A recent gene-expression profiling study, translated into a routine immunohistological test, identified genes of tumor-associated macrophages as being responsible for treatment outcome in patients with Hodgkin lymphoma. If this finding is confirmed by other investigators, it could be a major step towards personalized therapy for patients with Hodgkin lymphoma.
霍奇金淋巴瘤患者的预后模型并不完善，无法进行精确的个体化治疗。最近的一项基因表达谱研究转化为常规免疫组织化学检测，发现肿瘤相关巨噬细胞的基因与霍奇金淋巴瘤患者的治疗结果有关。如果这一发现得到其他研究人员的证实，这将是迈向霍奇金淋巴瘤患者个体化治疗的重要一步。
