Pfizer Inc., Groton, New London, CT, USA.
Br J Dermatol. 2010 Oct;163(4):683-8. doi: 10.1111/j.1365-2133.2010.09878.x.
Sebum excretion has generally been accepted as an important factor in the development of acne vulgaris. However, the relationship of sebum excretion and acne outcome has not yet been clearly demonstrated quantitatively. The objective of this analysis was to explore the correlation of sebum and acne by combining data from studies of various acne treatments that have demonstrated effects on both sebum excretion and acne outcome. Acne measures included total lesion count, inflammatory lesion count and acne severity grade. For each acne measure, data were pooled and analysed at the 3- and 4-month endpoints, when sebum reduction has generally equilibrated and efficacy in acne is approaching the maximum effect for most treatments. A linear model was used to describe the percentage reduction in each acne measure as a function of percentage reduction in sebum excretion. Slope values were similar for the three acne parameters and all were significantly different from zero (P < 0·025), suggesting a significant correlation of sebum and acne. The projected sebum reduction required to achieve 50% reduction in acne measures ranged from 30% to 50%. The results shown here suggest that the collective data across multiple studies may provide a useful generalization of the association of sebum reduction and acne outcome. As the relationship apparently remains consistent regardless of the treatment, it can be inferred that extrapolation to novel exploratory treatments may be valid.
皮脂分泌通常被认为是寻常痤疮发展的一个重要因素。然而，皮脂分泌与痤疮结局之间的关系尚未被明确地定量证明。本分析的目的是通过结合已证明对皮脂分泌和痤疮结局均有影响的各种痤疮治疗研究的数据，来探讨皮脂与痤疮之间的相关性。痤疮的衡量指标包括总皮损计数、炎性皮损计数和痤疮严重程度分级。对于每个痤疮衡量指标，在皮脂减少通常达到平衡且大多数治疗的痤疮疗效接近最大效应的 3 个月和 4 个月终点时，对数据进行汇总和分析。采用线性模型来描述每个痤疮衡量指标的减少百分比作为皮脂排泄减少百分比的函数。三个痤疮参数的斜率值相似，均显著不同于零（P＜0·025），提示皮脂与痤疮之间存在显著相关性。为了使痤疮衡量指标降低 50%，预计需要减少的皮脂量范围为 30%至 50%。这里显示的结果表明，多项研究的综合数据可能对皮脂减少与痤疮结局之间的关联提供有用的概括。由于该关系显然保持一致，无论治疗如何，都可以推断出向新的探索性治疗的外推可能是有效的。
