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抗氧化剂二羟甲基二乙己基羟苯甲酰基甲烷在治疗油性和瑕疵皮肤中的皮脂抑制功效。

Sebusuppressive efficacy of the antioxidant bis-ethylhexyl hydroxydimethoxy benzylmalonate in the treatment of oily and blemished skin.

机构信息

DermaTronnier, University of Witten-Herdecke, Witten, Germany.

出版信息

Clin Cosmet Investig Dermatol. 2012;5:101-9. doi: 10.2147/CCID.S32669. Epub 2012 Aug 20.

DOI:10.2147/CCID.S32669
PMID:22956882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3430093/
Abstract

The aim of this study was to assess the effect of 2% bis-ethylhexyl hydroxydimethoxy benzylmalonate (HDBM; RonaCare(®) AP) as an active ingredient in the treatment of oily and blemished skin. This study was carried out as a randomized, placebo-controlled, single-blind study on 44 test subjects with blemished skin over a period of 8 weeks. Sebum measurement, skin inflammation/redness scoring by an expert, photographic documentation and a self-assessment with regard to skin improvement, and tests of skin compatibility and galenic characteristics were performed. Treatment with 2% HDBM resulted in a significant reduction of sebum excretion and showed efficacy against inflamed/red lesions also shown by photographic documentation. Efficacy and galenic performance of 2% HDBM were judged to be superior to the placebo emulsion. Additionally, 2% HDBM was well tolerated; approximately 80% of the test subjects rated the compatibility as good to very good.

摘要

本研究旨在评估 2%双乙基己基羟二甲氧苯甲酰基甲烷（HDBM；RonaCare(®)AP）作为一种活性成分在治疗油性和瑕疵皮肤方面的效果。该研究在 44 名有瑕疵皮肤的受试者中进行了为期 8 周的随机、安慰剂对照、单盲研究。通过皮脂测量、专家进行皮肤炎症/发红评分、摄影记录以及关于皮肤改善的自我评估，以及皮肤相容性和赋形剂特性测试进行了评估。使用 2% HDBM 治疗可显著减少皮脂分泌，并通过摄影记录显示出对发炎/发红病变的疗效。2% HDBM 的疗效和赋形剂性能被认为优于安慰剂乳液。此外，2% HDBM 的耐受性良好；大约 80%的受试者对其相容性评价为好到非常好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/003b/3430093/6f5bd8bbf1cd/ccid-5-101f8.jpg
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4
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