KATP 通道在健康和疾病中的葡萄糖稳态中的作用：不仅仅是胰岛。
The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.
机构信息
Henry Wellcome Centre for Gene Function, Department of Physiology, Anatomy and Genetics, and OXION Centre for Ion Channel Studies, Sherrington Building, Parks Road, Oxford OX1 3PT, UK.
出版信息
J Physiol. 2010 Sep 1;588(Pt 17):3201-9. doi: 10.1113/jphysiol.2010.191767. Epub 2010 Jun 2.
Abstract
ATP-sensitive potassium (K(ATP)) channels are critical for the maintenance of glucose homeostasis. They are essential for glucose-stimulated insulin secretion from pancreatic beta-cells, contribute to the mechanisms by which hypoglycaemia stimulates glucagon release from pancreatic alpha-cells, and are involved in glucose uptake into skeletal muscle, glucose production and release from the liver, and feeding behaviour. Not surprisingly, loss- or gain-of-function mutations in K(ATP) channel genes have profound effects, giving rise to congenital hyperinsulinaemia and neonatal diabetes respectively. This symposium review focuses on our current understanding of the role of the K(ATP) channel in glucose homeostasis in health and disease.
摘要
三磷酸腺苷敏感性钾 (K(ATP)) 通道对于维持葡萄糖内环境稳定至关重要。它们对于胰腺β细胞的葡萄糖刺激胰岛素分泌是必需的，有助于低血糖刺激胰腺α细胞释放胰高血糖素的机制，并且参与骨骼肌摄取葡萄糖、肝脏葡萄糖产生和释放以及进食行为。毫不奇怪，K(ATP)通道基因的功能丧失或获得突变会产生深远的影响，分别导致先天性高胰岛素血症和新生儿糖尿病。本次专题讨论会回顾了我们目前对 K(ATP)通道在健康和疾病状态下葡萄糖内环境稳定中的作用的理解。
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