Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Istanbul, Türkiye.
Front Endocrinol (Lausanne). 2023 Jun 27;14:1156757. doi: 10.3389/fendo.2023.1156757. eCollection 2023.
Type 2 Diabetes Mellitus (T2DM) has been the main category of metabolic diseases in recent years due to changes in lifestyle and environmental conditions such as diet and physical activity. On the other hand, the circadian rhythm is one of the most significant biological pathways in humans and other mammals, which is affected by light, sleep, and human activity. However, this cycle is controlled via complicated cellular pathways with feedback loops. It is widely known that changes in the circadian rhythm can alter some metabolic pathways of body cells and could affect the treatment process, particularly for metabolic diseases like T2DM. The aim of this study is to explore the importance of the circadian rhythm in the occurrence of T2DM via reviewing the metabolic pathways involved, their relationship with the circadian rhythm from two perspectives, lifestyle and molecular pathways, and their effect on T2DM pathophysiology. These impacts have been demonstrated in a variety of studies and led to the development of approaches such as time-restricted feeding, chronotherapy (time-specific therapies), and circadian molecule stabilizers.
2 型糖尿病（T2DM）近年来已成为代谢疾病的主要类别，这是由于饮食和身体活动等生活方式和环境条件的变化。另一方面，昼夜节律是人类和其他哺乳动物最重要的生物途径之一，受光、睡眠和人类活动的影响。然而，这个周期是通过复杂的细胞途径和反馈环来控制的。众所周知，昼夜节律的变化会改变体细胞的一些代谢途径，并可能影响治疗过程，特别是对 T2DM 等代谢疾病的治疗过程。本研究旨在通过回顾涉及的代谢途径，从生活方式和分子途径两个角度探讨昼夜节律在 T2DM 发生中的重要性，以及它们对 T2DM 病理生理学的影响。这些影响在各种研究中得到了证实，并导致了限时喂养、时间治疗（时间特异性治疗）和昼夜节律分子稳定剂等方法的发展。
