Department of Virology, Tropical Medicine Institute "Pedro Kourí," Havana, Cuba.
Am J Trop Med Hyg. 2010 Jun;82(6):1153-6. doi: 10.4269/ajtmh.2010.09-0353.
The role of human Fcgamma receptors (FcgammaR) has been recognized considerably over the last years. These receptors vary in their affinity for IgG subclasses and the intracellular signals elicited by them. Allelic variants of FcgammaR genes may influence the biological phagocyte activity, accounting for an inherited pre-disposition to disease. The specific FcgammaRIIa (CD32) contains a polymorphic variant (H/R131) that has been associated to a reduced risk for developing dengue hemorrhagic fever (DHF). Here, we investigated the role of this polymorphism in a very well-characterized group of Cuban individuals with antecedents of DHF, dengue fever (DF), or subclinical dengue infection. The HH131 genotype was significantly associated with dengue disease, either DF (*P = 0.016; odds ratio = 4.425; 95% confidence interval = 1.10-20.52) or DHF (P = 0.00018; odds ratio = 10.56; 95% confidence interval = 2.33-54.64) with respect to the subclinical infection.
近年来，人们对人类 Fcγ 受体（FcγR）的作用有了相当多的认识。这些受体在其对 IgG 亚类的亲和力和它们引发的细胞内信号方面存在差异。FcγR 基因的等位基因变体可能影响吞噬细胞的生物学活性，从而导致疾病的遗传易感性。特定的 FcγRIIa（CD32）含有一个多态性变体（H/R131），与发生登革出血热（DHF）的风险降低有关。在这里，我们研究了这种多态性在一组具有 DHF、登革热（DF）或亚临床登革感染病史的古巴个体中的作用。HH131 基因型与登革热疾病显著相关，无论是 DF（*P = 0.016；优势比 = 4.425；95%置信区间 = 1.10-20.52）还是 DHF（P = 0.00018；优势比 = 10.56；95%置信区间 = 2.33-54.64），与亚临床感染相比。
