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Cell lineage determination in state space: a systems view brings flexibility to dogmatic canonical rules.

作者信息

Huang Sui

机构信息

Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Canada.

出版信息

PLoS Biol. 2010 May 25;8(5):e1000380. doi: 10.1371/journal.pbio.1000380.

DOI:10.1371/journal.pbio.1000380
PMID:20520792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2876052/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd7/2876052/4299b4637d16/pbio.1000380.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd7/2876052/4299b4637d16/pbio.1000380.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd7/2876052/4299b4637d16/pbio.1000380.g001.jpg

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Biophys J. 2010 Jul 7;99(1):29-39. doi: 10.1016/j.bpj.2010.03.058.
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Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript.通过早期内胚层转录本的翻译扩增揭示胚胎干细胞的功能异质性。
PLoS Biol. 2010 May 25;8(5):e1000379. doi: 10.1371/journal.pbio.1000379.
3
Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.
新型通用干细胞分化模型揭示了振荡机制。
J R Soc Interface. 2021 Oct;18(183):20210442. doi: 10.1098/rsif.2021.0442. Epub 2021 Oct 6.
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Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities.在 ETV6-RUNX1 阳性小儿白血病的化疗过程中对 B 淋巴细胞分化和白血病细胞状态进行单细胞特征分析，确定了可靶向药物的转录因子活性。
Genome Med. 2020 Nov 20;12(1):99. doi: 10.1186/s13073-020-00799-2.
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Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome.心脏生成干细胞疗法可恢复梗死改变的心脏蛋白质组。
NPJ Regen Med. 2020 Mar 12;5:5. doi: 10.1038/s41536-020-0091-6. eCollection 2020.
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Exploring intermediate cell states through the lens of single cells.通过单细胞视角探索中间细胞状态。
Curr Opin Syst Biol. 2018 Jun;9:32-41. doi: 10.1016/j.coisb.2018.02.009. Epub 2018 Mar 2.
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Drawing on disorder: How viruses use histone mimicry to their advantage.利用紊乱：病毒如何利用组蛋白模拟来获取优势。
J Exp Med. 2018 Jul 2;215(7):1777-1787. doi: 10.1084/jem.20180099. Epub 2018 Jun 22.
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