状态空间中的细胞谱系决定：系统视角为教条式的经典规则带来灵活性。 - Suppr

Suppr

超能文献

Cell lineage determination in state space: a systems view brings flexibility to dogmatic canonical rules.

作者信息

Huang Sui

机构信息

Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Canada.

出版信息

PLoS Biol. 2010 May 25;8(5):e1000380. doi: 10.1371/journal.pbio.1000380.

DOI:10.1371/journal.pbio.1000380

PMID:20520792

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2876052/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fd7/2876052/4299b4637d16/pbio.1000380.g001.jpg

相似文献

Cell lineage determination in state space: a systems view brings flexibility to dogmatic canonical rules.状态空间中的细胞谱系决定：系统视角为教条式的经典规则带来灵活性。

PLoS Biol. 2010 May 25;8(5):e1000380. doi: 10.1371/journal.pbio.1000380.

Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers.利用一个不重叠的追踪系统对三个胚层的小鼠胚胎和成年个体进行发育分析。

Development. 2019 Nov 4;146(21):dev174938. doi: 10.1242/dev.174938.

Whsc1 links pluripotency exit with mesendoderm specification.Whsc1 将多能性退出与中胚层指定联系起来。

Nat Cell Biol. 2019 Jul;21(7):824-834. doi: 10.1038/s41556-019-0342-1. Epub 2019 Jun 24.

Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast.Nanog启动子中Otx2结合位点的缺失影响胚胎干细胞亚型的完整性及内细胞团来源的上胚层的特化。

Cell Rep. 2016 Jun 21;15(12):2651-64. doi: 10.1016/j.celrep.2016.05.041. Epub 2016 Jun 9.

Transcriptional profiling of human embryonic stem cells differentiating to definitive and primitive endoderm and further toward the hepatic lineage.人类胚胎干细胞向确定内胚层和原始内胚层分化并进一步向肝系分化的转录谱分析。

Stem Cells Dev. 2010 Jul;19(7):961-78. doi: 10.1089/scd.2009.0220.

Hematopoietic progenitors express embryonic stem cell and germ layer genes.造血祖细胞表达胚胎干细胞和胚层基因。

C R Biol. 2011 Apr;334(4):300-6. doi: 10.1016/j.crvi.2011.02.005. Epub 2011 Mar 25.

Generation of organized germ layers from a single mouse embryonic stem cell.从单个小鼠胚胎干细胞生成有组织的胚层。

Nat Commun. 2014 May 30;5:4000. doi: 10.1038/ncomms5000.

Differential response of epiblast stem cells to Nodal and Activin signalling: a paradigm of early endoderm development in the embryo.上胚层干细胞对Nodal和激活素信号的差异反应：胚胎早期内胚层发育的范例

Philos Trans R Soc Lond B Biol Sci. 2014 Dec 5;369(1657). doi: 10.1098/rstb.2013.0550.

Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.胚胎干细胞向表达Pdx1的区域特异性定形内胚层的定向分化。

Stem Cells. 2008 Apr;26(4):874-85. doi: 10.1634/stemcells.2007-0608. Epub 2008 Jan 31.

Actl6a protects embryonic stem cells from differentiating into primitive endoderm.Actl6a 可防止胚胎干细胞分化为原始内胚层。

Stem Cells. 2015 Jun;33(6):1782-93. doi: 10.1002/stem.2000.

引用本文的文献

Metabolic adaptation pilots the differentiation of human hematopoietic cells.代谢适应驱动人类造血细胞的分化。

Life Sci Alliance. 2024 May 27;7(8). doi: 10.26508/lsa.202402747. Print 2024 Aug.

Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic cells.全球基因组解压缩导致人类造血细胞命运决定的第一步是基因表达的随机激活。

PLoS Biol. 2022 Oct 26;20(10):e3001849. doi: 10.1371/journal.pbio.3001849. eCollection 2022 Oct.

Novel generic models for differentiating stem cells reveal oscillatory mechanisms.新型通用干细胞分化模型揭示了振荡机制。

J R Soc Interface. 2021 Oct;18(183):20210442. doi: 10.1098/rsif.2021.0442. Epub 2021 Oct 6.

Single cell characterization of B-lymphoid differentiation and leukemic cell states during chemotherapy in ETV6-RUNX1-positive pediatric leukemia identifies drug-targetable transcription factor activities.在 ETV6-RUNX1 阳性小儿白血病的化疗过程中对 B 淋巴细胞分化和白血病细胞状态进行单细胞特征分析，确定了可靶向药物的转录因子活性。

Genome Med. 2020 Nov 20;12(1):99. doi: 10.1186/s13073-020-00799-2.

Cardiopoietic stem cell therapy restores infarction-altered cardiac proteome.心脏生成干细胞疗法可恢复梗死改变的心脏蛋白质组。

NPJ Regen Med. 2020 Mar 12;5:5. doi: 10.1038/s41536-020-0091-6. eCollection 2020.

Exploring intermediate cell states through the lens of single cells.通过单细胞视角探索中间细胞状态。

Curr Opin Syst Biol. 2018 Jun;9:32-41. doi: 10.1016/j.coisb.2018.02.009. Epub 2018 Mar 2.

Drawing on disorder: How viruses use histone mimicry to their advantage.利用紊乱：病毒如何利用组蛋白模拟来获取优势。

J Exp Med. 2018 Jul 2;215(7):1777-1787. doi: 10.1084/jem.20180099. Epub 2018 Jun 22.

Gene Regulatory Network Inference from Single-Cell Data Using Multivariate Information Measures.基于多元信息测度的单细胞数据基因调控网络推断

Cell Syst. 2017 Sep 27;5(3):251-267.e3. doi: 10.1016/j.cels.2017.08.014.

Network modelling of gene regulation.基因调控的网络建模

Biophys Rev. 2011 Mar;3(1):1-13. doi: 10.1007/s12551-010-0041-4. Epub 2010 Dec 23.

Cell Fate Decision as High-Dimensional Critical State Transition.细胞命运决定作为高维临界状态转变

PLoS Biol. 2016 Dec 27;14(12):e2000640. doi: 10.1371/journal.pbio.2000640. eCollection 2016 Dec.

本文引用的文献

The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation.遗传回路的潜在景观在干细胞分化中引入了时间之箭。

Biophys J. 2010 Jul 7;99(1):29-39. doi: 10.1016/j.bpj.2010.03.058.

Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript.通过早期内胚层转录本的翻译扩增揭示胚胎干细胞的功能异质性。

PLoS Biol. 2010 May 25;8(5):e1000379. doi: 10.1371/journal.pbio.1000379.

Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo.小鼠胚胎内细胞团最初的两种不同细胞类型的起源和形成。

Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6364-9. doi: 10.1073/pnas.0915063107. Epub 2010 Mar 22.

Hes1 oscillation: making variable choices for stem cell differentiation.Hes1振荡：为干细胞分化做出多样选择。

Cell Cycle. 2010 Jan 15;9(2):207-8. doi: 10.4161/cc.9.2.10478. Epub 2010 Jan 30.

Forcing cells to change lineages.迫使细胞改变谱系。

Nature. 2009 Dec 3;462(7273):587-94. doi: 10.1038/nature08533.

Non-genetic heterogeneity of cells in development: more than just noise.发育过程中细胞的非遗传异质性：不止是噪声。

Development. 2009 Dec;136(23):3853-62. doi: 10.1242/dev.035139.

A continuum of cell states spans pluripotency and lineage commitment in human embryonic stem cells.人胚胎干细胞的多能性和谱系特化之间存在细胞状态的连续谱。

PLoS One. 2009 Nov 5;4(11):e7708. doi: 10.1371/journal.pone.0007708.

Systems biology of stem cell fate and cellular reprogramming.干细胞命运与细胞重编程的系统生物学

Nat Rev Mol Cell Biol. 2009 Oct;10(10):672-81. doi: 10.1038/nrm2766. Epub 2009 Sep 9.

Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.Nanog表达的规律性波动介导胚胎干细胞的细胞命运决定。

PLoS Biol. 2009 Jul;7(7):e1000149. doi: 10.1371/journal.pbio.1000149. Epub 2009 Jul 7.

Reprogramming cell fates: reconciling rarity with robustness.重编程细胞命运：兼顾稀有性与稳健性。

Bioessays. 2009 May;31(5):546-60. doi: 10.1002/bies.200800189.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验