AMPK 的抑制作用：在健康与疾病中的影响
AMPK inhibition in health and disease.
机构信息
Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France.
出版信息
Crit Rev Biochem Mol Biol. 2010 Aug;45(4):276-95. doi: 10.3109/10409238.2010.488215.
Abstract
All living organisms depend on dynamic mechanisms that repeatedly reassess the status of amassed energy, in order to adapt energy supply to demand. The AMP-activated protein kinase (AMPK) alphabetagamma heterotrimer has emerged as an important integrator of signals managing energy balance. Control of AMPK activity involves allosteric AMP and ATP regulation, auto-inhibitory features and phosphorylation of its catalytic (alpha) and regulatory (beta and gamma) subunits. AMPK has a prominent role not only as a peripheral sensor but also in the central nervous system as a multifunctional metabolic regulator. AMPK represents an ideal second messenger for reporting cellular energy state. For this reason, activated AMPK acts as a protective response to energy stress in numerous systems. However, AMPK inhibition also actively participates in the control of whole body energy homeostasis. In this review, we discuss recent findings that support the role and function of AMPK inhibition under physiological and pathological states.
摘要
所有生物体都依赖于动态机制，这些机制反复评估积累能量的状态，以适应能量供应和需求。AMP 激活的蛋白激酶（AMPK）αγ异三聚体已成为管理能量平衡的信号的重要整合因子。AMPK 活性的控制涉及变构 AMP 和 ATP 调节、自动抑制特性以及其催化（α）和调节（β和γ）亚基的磷酸化。AMPK 不仅作为外周传感器，而且在中枢神经系统中作为多功能代谢调节剂发挥着重要作用。AMPK 是报告细胞能量状态的理想第二信使。出于这个原因，激活的 AMPK 作为对许多系统中能量应激的保护性反应。然而，AMPK 抑制也积极参与全身能量稳态的控制。在这篇综述中，我们讨论了支持生理和病理状态下 AMPK 抑制作用和功能的最新发现。
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