Hanna C B
Oral Surg Oral Med Oral Pathol. 1991 Apr;71(4):496-8. doi: 10.1016/0030-4220(91)90439-j.
The objectives of this prospective single-blind trial were to compare the efficacy and safety of cefadroxil, 1 gm/day, and cephalexin, 250 mg four times a day, in the treatment of facial cellulitis of odontogenic origin. One hundred sixteen patients were screened for sensitivity to the assigned antibiotic and then randomly assigned treatment groups. Fifty-eight (100%) of the cefadroxil-treated patients and 57 (98%) of the cephalexin-treated patients were considered cured. Adverse reactions were noted in only two cefadroxil-treated patients and one cephalexin-treated patient. One patient from each group discontinued therapy prematurely; the patient who discontinued cephalexin was the only treatment failure in this study. This study found that cefadroxil administered once a day was therapeutically equivalent to cephalexin given four times a day.
这项前瞻性单盲试验的目的是比较每日1克头孢羟氨苄与每日四次、每次250毫克头孢氨苄治疗牙源性面部蜂窝织炎的疗效和安全性。116名患者接受了指定抗生素的敏感性筛查，然后随机分配到治疗组。头孢羟氨苄治疗组的58名患者（100%）和头孢氨苄治疗组的57名患者（98%）被认为治愈。仅在两名头孢羟氨苄治疗的患者和一名头孢氨苄治疗的患者中发现了不良反应。每组各有一名患者提前终止治疗；停用头孢氨苄的患者是本研究中唯一的治疗失败病例。本研究发现，每日给药一次的头孢羟氨苄与每日给药四次的头孢氨苄在治疗效果上相当。
