Park Hoon, Kim Chul Woo, Kim Sang Seok, Park Chun Wook
Department of Dermatology, College of Medicine, Hallym University, Seoul, Korea.
Ann Dermatol. 2009 May;21(2):142-6. doi: 10.5021/ad.2009.21.2.142. Epub 2009 May 31.
It has been reported that some alopecia areata patients have zinc deficiency. There have also been several reports published concerning oral zinc sulfate therapy, with encouraging results, in some alopecia areata patients.
The purpose of this study was to evaluate the therapeutic effects of oral zinc supplementation for twelve weeks in alopecia areata patients who had a low serum zinc level.
Oral zinc gluconate (50 mg/T/day) supplementation was given to alopecia areata patients without any other treatment for twelve weeks. The serum zinc level was measured before and after zinc supplementation. A four-point scale of hair regrowth was used to evaluate the therapeutic effect of oral zinc supplementation in these patients.
Fifteen alopecia areata patients were enrolled in this study. After the therapy, the serum zinc levels increased significantly from 56.9 microg/ to 84.5 microg/dl. Positive therapeutic effects were observed for 9 out of 15 patients (66.7%) although this was not statistically significant. The serum zinc levels of the positive response group increased more than those of the negative response group (p=0.003).
Zinc supplementation needs to be given to the alopecia areata patients who have a low serum zinc level. We suggest that zinc supplementation could become an adjuvant therapy for the alopecia areata patients with a low serum zinc level and for whom the traditional therapeutic methods have been unsuccessful.
据报道，一些斑秃患者存在锌缺乏情况。也有几篇关于口服硫酸锌疗法的报道，在一些斑秃患者中取得了令人鼓舞的结果。
本研究的目的是评估血清锌水平低的斑秃患者口服补充锌12周的治疗效果。
给予斑秃患者口服葡萄糖酸锌（50毫克/天），为期12周，期间不进行任何其他治疗。在补锌前后测量血清锌水平。使用四点毛发再生量表来评估这些患者口服补锌的治疗效果。
15名斑秃患者纳入本研究。治疗后，血清锌水平从56.9微克/分升显著升至84.5微克/分升。15名患者中有9名（66.7%）观察到了积极的治疗效果，尽管这在统计学上不显著。阳性反应组的血清锌水平比阴性反应组升高得更多（p=0.003）。
血清锌水平低的斑秃患者需要补充锌。我们建议，对于血清锌水平低且传统治疗方法无效的斑秃患者，补锌可成为一种辅助治疗方法。
