Bae You In, Yun Sook-Jung, Lee Jee-Bum, Kim Seong-Jin, Won Young Ho, Lee Seung-Chul
Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
Ann Dermatol. 2009 Aug;21(3):243-9. doi: 10.5021/ad.2009.21.3.243. Epub 2009 Aug 31.
Although rosacea is a chronic cutaneous inflammatory disorder that's commonly seen in adults, the etiology and pathogenesis of the illness remain unclear. A well established diagnostic classification and grading system may play a critical role in performing research and it would serve as a diagnostic reference in the clinical field.
We sought to classify the patients with the new standard classification and grading system and we wanted determine the peculiar features and relationships of each subtype. We also analyzed the relationships between the degree of sun exposure and each subtype.
We reviewed the medical records and clinical photos of 168 patients who were diagnosed with rosacea from 2002 to 2007 at our hospital. The standard classification and grading system suggested by the National Rosacea Society (NRS) Expert Committee was adopted to evaluate each patient's subtype and the severity.
The male:female ratio was 1:2.29. The mean age at the time of diagnosis was 47.8 years. The mean duration of disease was 3.5 years. Sun exposure and hot baths/exercise were the two most common precipitating factors, while the majority of patients did not have any specific factor that relieved their symptoms. According to the NRS classification and grading system, the patients were classified into four subtypes. One hundred sixty two (96.4%) patients were diagnosed with the erythematotelangiectatic subtype irrespective of severity. Eighty five (50.6%) patients had the papulopustular subtype and 24 (14.3%) patients had ocular rosacea. Eight (4.8%) patients displayed mild phymatous change. The degree of sun exposure had significant correlation with the development and severity of the erythematotelangiectatic subtype (p<0.05), while it had no correlation with the papulopustular, ocular and phymatous subtypes.
Although the erythematotelangiectatic subtype was the most common subtype of rosacea, many patients also had other subtypes of rosacea simultaneously. Based on our results, we proved that ocular rosacea is an extension of the clinical spectrum of erythematotelangiectatic rosacea. In addition, the results of our study particularly suggest that sun exposure has a different influence on each subtype of rosacea.
虽然酒渣鼻是一种常见于成年人的慢性皮肤炎症性疾病，但其病因和发病机制仍不清楚。完善的诊断分类和分级系统可能在开展研究中发挥关键作用，并且可作为临床领域的诊断参考。
我们试图用新的标准分类和分级系统对患者进行分类，并确定各亚型的独特特征及相互关系。我们还分析了日晒程度与各亚型之间的关系。
我们回顾了2002年至2007年在我院被诊断为酒渣鼻的168例患者的病历和临床照片。采用美国酒渣鼻协会（NRS）专家委员会建议的标准分类和分级系统来评估每位患者的亚型和严重程度。
男女比例为1:2.29。诊断时的平均年龄为47.8岁。疾病的平均病程为3.5年。日晒和热水浴/运动是两个最常见的诱发因素，而大多数患者没有任何缓解症状的特定因素。根据NRS分类和分级系统，患者被分为四个亚型。162例（96.4%）患者被诊断为红斑毛细血管扩张型，无论严重程度如何。85例（50.6%）患者有丘疹脓疱型，24例（14.3%）患者有眼型酒渣鼻。8例（4.8%）患者表现出轻度的鼻赘改变。日晒程度与红斑毛细血管扩张型的发生和严重程度显著相关（p<0.05），而与丘疹脓疱型、眼型和鼻赘型无关。
虽然红斑毛细血管扩张型是酒渣鼻最常见的亚型，但许多患者同时也有其他亚型的酒渣鼻。基于我们的结果，我们证明眼型酒渣鼻是红斑毛细血管扩张型酒渣鼻临床谱的延伸。此外，我们的研究结果特别表明日晒对酒渣鼻的各亚型有不同的影响。
