Lonne-Rahm S B, Fischer T, Berg M
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Acta Derm Venereol. 1999 Nov;79(6):460-1. doi: 10.1080/000155599750009915.
A total of 32 rosacea patients (25 with the papulopustular type of rosacea and 7 with the erythematotelangiectatic type) and 32 healthy persons were single-blind tested with a solution of 5% lactic acid and pure water applied to their cheeks. Twenty-four patients and 6 controls reacted positively as "stingers" (p<0.001) in this objective test of sensitive skin. All 7 of the patients with erythematotelangiectatic rosacea, but only 17/25 with the papulopustular type, were stingers (n.s.). The reason why some patients react with subjective symptoms, such as itching, burning, stinging, prickling or tingling, is unclear. The findings in this study are not surprising, but do support the theory that impairment due to different stimuli, most likely because of vascular sensitivity, is a central mechanism in the aetiology of rosacea. The correlation between sensitive vessels and sensitive skin has, however, not yet been determined.
共有32名酒渣鼻患者(25名丘疹脓疱型酒渣鼻患者和7名红斑毛细血管扩张型酒渣鼻患者)和32名健康人参与了一项单盲测试,在他们的脸颊上分别涂抹5%乳酸溶液和纯水。在这项针对敏感性皮肤的客观测试中,24名患者和6名对照者呈“刺痛者”阳性反应(p<0.001)。所有7名红斑毛细血管扩张型酒渣鼻患者均为“刺痛者”,但丘疹脓疱型患者中只有17/25是“刺痛者”(无显著差异)。一些患者出现瘙痒、灼痛、刺痛、针扎感或麻刺感等主观症状的原因尚不清楚。本研究的结果并不令人惊讶,但确实支持了这样一种理论,即不同刺激导致的损伤,很可能是由于血管敏感性,是酒渣鼻病因学的核心机制。然而,敏感血管与敏感性皮肤之间的相关性尚未确定。