Schmidt-Pokrzywniak Andrea, Jöckel Karl-Heinz, Bornfeld Norbert, Stang Andreas
Institute of Medical Informatics, Biometry and Epidemiology, University Hospital, University of Duisburg-Essen, Hufelandstr, 55, 45122 Essen, Germany.
BMC Ophthalmol. 2004 Aug 19;4:11. doi: 10.1186/1471-2415-4-11.
Although a rare disease, uveal melanoma is the most common primary intraocular malignancy in adults, with an incidence rate of up to 1.0 per 100,000 persons per year in Europe. Only a few consistent risk factors have been identified for this disease. We present the study design of an ongoing incident case-control study on uveal melanoma (acronym: RIFA study) that focuses on radiofrequency radiation as transmitted by radio sets and wireless telephones, occupational risk factors, phenotypical characteristics, and UV radiation.
METHODS/DESIGN: We conduct a case-control study to identify the role of different exposures in the development of uveal melanoma. The cases of uveal melanoma were identified at the Division of Ophthalmology, University of Essen, a referral centre for tumours of the eye. We recruit three control groups: population controls, controls sampled from those ophthalmologists who referred cases to the Division of Ophthalmology, University of Duisburg-Essen, and sibling controls. For each case the controls are matched on sex and age (five year groups), except for sibling controls. The data are collected from the study participants by short self-administered questionnaire and by telephone interview. During and at the end of the field phase, the data are quality-checked. To estimate the effect of exposures on uveal melanoma risk, we will use conditional logistic regression that accounts for the matching factors and allows to control for potential confounding.
葡萄膜黑色素瘤虽属罕见疾病，但却是成人中最常见的原发性眼内恶性肿瘤，在欧洲其发病率高达每年每10万人中有1.0例。针对该疾病，仅确定了少数几个一致的风险因素。我们介绍了一项正在进行的葡萄膜黑色素瘤病例对照研究（缩写：RIFA研究）的研究设计，该研究聚焦于收音机和无线电话所发射的射频辐射、职业风险因素、表型特征以及紫外线辐射。
方法/设计：我们开展一项病例对照研究，以确定不同暴露因素在葡萄膜黑色素瘤发病过程中的作用。葡萄膜黑色素瘤病例在埃森大学眼科分部确定，该分部是眼部肿瘤转诊中心。我们招募三个对照组：人群对照组、从那些将病例转诊至杜伊斯堡 - 埃森大学眼科分部的眼科医生中抽取的对照组以及同胞对照组。对于每个病例，除同胞对照组外，对照组在性别和年龄（五岁一组）上进行匹配。数据通过简短的自我填写问卷和电话访谈从研究参与者处收集。在现场调查阶段期间及结束时，对数据进行质量检查。为了估计暴露因素对葡萄膜黑色素瘤风险的影响，我们将使用条件逻辑回归，该方法考虑了匹配因素并能够控制潜在的混杂因素。
