Gozalo Alfonso S, Zerfas Patricia M, Starost Matthew F, Elkins William R, Clarke Carol L
Comparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
J Med Primatol. 2010 Dec;39(6):385-8. doi: 10.1111/j.1600-0684.2010.00425.x.
An adult male owl monkey (Aotus nancymae) underwent a splenectomy. When the spleen was removed, a small, nodular mass slightly bulging over the splenic surface was noted.
The mass was examined by light and transmission electron microscopy and by immunohistochemistry.
On light microscopy, the mass was well-circumscribed, non-encapsulated, and composed of haphazardly arranged smooth muscle bundles admixed with numerous small capillary-like structures containing blood. Immunohistochemical (IHC) staining revealed the tumor was strongly positive for smooth muscle actin yielding vascular smooth muscle bundles, and for Factor VIII, staining endothelial cells within the smooth muscle bundles. Transmission electron microscopy (TEM) showed a large portion of the cells to be atypical appearing smooth muscle and a few cells had structures resembling Weibel-Palade bodies indicating endothelial cells.
Based on cell morphology, by light and TEM, and IHC a final diagnosis of splenic angioleiomyoma was made. This is, to our knowledge, the first report of an angioleiomyoma in a non-human primate.
一只成年雄性夜猴（南希夜猴）接受了脾切除术。切除脾脏时，发现脾脏表面有一个小的结节状肿块，略微隆起。
对该肿块进行了光镜、透射电镜检查及免疫组化分析。
光镜下，肿块边界清晰，无包膜，由杂乱排列的平滑肌束组成，混有许多含血液的小毛细血管样结构。免疫组化（IHC）染色显示，肿瘤对平滑肌肌动蛋白呈强阳性反应，提示血管平滑肌束，对因子VIII呈阳性反应，表明平滑肌束内的内皮细胞染色。透射电镜（TEM）显示大部分细胞为非典型的平滑肌细胞，少数细胞具有类似魏贝尔-帕拉德小体的结构，提示为内皮细胞。
基于光镜、透射电镜下的细胞形态及免疫组化结果，最终诊断为脾血管平滑肌瘤。据我们所知，这是首例在非人类灵长类动物中发现的血管平滑肌瘤报告。
