Department of Surgery, Massachusetts General Hospital, Harvard Medical School, and the Shriners Hospitals for Children, Center for Engineering in Medicine, Boston, MA 76104, USA.
Cell Transplant. 2010;19(6):655-65. doi: 10.3727/096368910X508753. Epub 2010 Jun 3.
Cell populations derived from adult tissue and stem cells possess a great expectation for the treatment of several diseases. Great efforts have been made to generate cells with therapeutic impact from stem cells. However, it is clear that the development of systems to deliver such cells to induce efficient engraftment, growth, and function is a real necessity. Biologic and artificial scaffolds have received significant attention for their potential therapeutic application when use to form tissues in vitro and facilitate engraftment in vivo. Ultimately more sophisticated methods for decellularization of organs have been successfully used in tissue engineering and regenerative medicine applications. These decellularized tissues and organs appear to provide bioactive molecules and bioinductive properties to induce homing, differentiation, and proliferation of cells. The combination of decellularized organs and stem cells may dramatically improve the survival, engraftment, and fate control of transplanted stem cells and their ultimate clinical utility, opening the doors to a new era of organ engineering.
从成体组织和干细胞中衍生的细胞群体为治疗多种疾病带来了很大的希望。人们已经做出了巨大的努力，试图从干细胞中产生具有治疗效果的细胞。然而，很明显，开发将这些细胞递送到体内以诱导有效植入、生长和功能的系统是真正必要的。生物和人工支架因其在体外形成组织和促进体内植入的潜在治疗应用而受到广泛关注。最终，更复杂的器官脱细胞方法已成功应用于组织工程和再生医学应用中。这些脱细胞组织和器官似乎提供了生物活性分子和生物诱导特性，以诱导细胞归巢、分化和增殖。脱细胞器官和干细胞的结合可能会极大地提高移植干细胞的存活率、植入率和命运控制，并最终提高其临床应用效果，为器官工程的新时代开辟了道路。
