Nat Cell Biol. 2010 Jul;12(7):640-1. doi: 10.1038/ncb2076.
The importin-beta-like transport receptors and RanGTP govern selective transport of proteins into the nucleus. It has now been shown that importin-beta2 (alternatively called transportin1) also selectively targets the motor protein Kif17 to primary cilia. In analogy to the nucleus, RanGTP in the intraciliary compartment mediates dissociation of Kif17 from its transport receptor and thereby completes import.
输入蛋白-β样转运受体和 RanGTP 调控蛋白选择性入核。目前研究表明输入蛋白-β2（又称作转运蛋白 1）还可将动力蛋白 Kif17 靶向到初级纤毛。类似细胞核，纤毛内的 RanGTP 介导 Kif17 与其转运受体的解离，从而完成蛋白输入。
