Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Medical Faculty Mannheim, Mannheim, Germany.
Nat Neurosci. 2010 Aug;13(8):920-2. doi: 10.1038/nn.2572. Epub 2010 Jun 6.
Structural remodeling has been observed in the human brain over periods of weeks to months, but the molecular mechanisms governing this process remain incompletely characterized. Using multimodal pharmaco-neuroimaging, we found that acute D2 receptor blockade induced reversible striatal volume changes and structural-functional decoupling in motor circuits within hours; these alterations predicted acute extrapyramidal motor symptoms with high precision. Our findings suggest a role for D2 receptors in short-term neural plasticity and identify a potential biomarker for neuroleptic side effects in humans.
在数周到数月的时间内，人们观察到了人类大脑的结构重塑，但调控这一过程的分子机制仍不完全清楚。采用多模态药物神经影像学，我们发现，D2 受体的急性阻断会在数小时内引起纹状体体积的可逆变化以及运动回路的结构-功能解耦；这些改变能够高精度地预测急性锥体外系运动症状。我们的发现表明 D2 受体在短期神经可塑性中发挥作用，并确定了一种潜在的神经安定药副作用的生物标志物。
