Menezes Luis Fernando, Germino Gregory G
Kidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Wiley Interdiscip Rev Syst Biol Med. 2015 Jan-Feb;7(1):39-52. doi: 10.1002/wsbm.1289. Epub 2015 Feb 2.
The proliferation and diminishing costs of 'omics' approaches have finally opened the doors for small and medium laboratories to enter the 'systems biology era'. This is a welcome evolution that requires a new framework to design, interpret, and validate studies. Here, we highlight some of the challenges, contributions, and prospects of the 'cyst-ems biology' of polycystic kidney disease.
“组学”方法的不断发展及其成本的降低,终于为中小型实验室打开了进入“系统生物学时代”的大门。这是一个令人欣喜的发展,需要一个新的框架来设计、解读和验证研究。在此,我们重点介绍多囊肾病“系统生物学”面临的一些挑战、贡献和前景。