Department of Medical Technology, Institute of Biomedicine, University of Oulu, PO Box 5000, 90014, Oulu, Finland.
Calcif Tissue Int. 2010 Jul;87(1):44-51. doi: 10.1007/s00223-010-9382-z. Epub 2010 Jun 5.
We evaluated the contribution of lifestyle-related factors, calcaneal ultrasound, and radial bone mineral density (BMD) to cervical and trochanteric hip fractures in elderly women in a 10-year population-based cohort study. The study population consisted of 1,681 women (age range 70-73 years). Seventy-two percent (n = 1,222) of them participated in the baseline measurements. Calcaneal ultrasound was assessed with a quantitative ultrasound device. BMD measurements were performed at the distal and ultradistal radius by dual-energy X-ray absorptiometry. Forward stepwise logistic regression analysis was used to find the most predictive variables for hip fracture risk. During the follow-up, 53 of the women had hip fractures, including 32 cervical and 21 trochanteric ones. The fractured women were taller and thinner and had lower calcaneal ultrasound values than those without fractures. High body mass index (BMI) was a protective factor against any hip fractures, while low functional mobility was a risk factor of hip fractures. Specifically, high BMI protected against cervical hip fractures, while low physical activity was a significant predictor of these fractures. Similarly, high BMI protected against trochanteric fractures, whereas low functional mobility and high coffee consumption were significant predictors of trochanteric fractures. Cervical and trochanteric hip fractures seem to have different risk factors. Therefore, fracture type should be taken into account in clinical fracture risk assessment and preventative efforts, including patient counseling. However, the study is not conclusive due to the limited number of observed fractures during follow-up, and the results have to be confirmed in future studies.
我们在一项为期 10 年的基于人群的队列研究中评估了与生活方式相关的因素、跟骨超声和桡骨骨密度(BMD)对老年女性颈椎和股骨转子部髋部骨折的贡献。研究人群包括 1681 名女性(年龄在 70-73 岁之间)。其中 72%(n=1222)的人参加了基线测量。使用定量超声设备评估跟骨超声。通过双能 X 射线吸收法在桡骨远端和超远端测量 BMD。采用向前逐步逻辑回归分析来寻找髋部骨折风险的最具预测性变量。在随访期间,53 名女性发生了髋部骨折,包括 32 例颈椎骨折和 21 例股骨转子部骨折。骨折女性比无骨折女性更高、更瘦,跟骨超声值更低。高身体质量指数(BMI)是预防任何髋部骨折的保护因素,而低功能移动性是髋部骨折的风险因素。具体而言,高 BMI 可预防颈椎髋部骨折,而低体力活动是这些骨折的重要预测指标。同样,高 BMI 可预防股骨转子部骨折,而低功能移动性和高咖啡摄入量是股骨转子部骨折的重要预测指标。颈椎和股骨转子部髋部骨折似乎有不同的危险因素。因此,在临床骨折风险评估和预防工作中,包括对患者的咨询,应考虑骨折类型。然而,由于随访期间观察到的骨折数量有限,研究结果尚需在未来的研究中进一步证实,因此该研究尚不确定。